Document Detail

Is Previous Respiratory Disease a Risk Factor for Lung Cancer?
MedLine Citation:
PMID:  25054566     Owner:  NLM     Status:  Publisher    
Rationale: Previous respiratory diseases have been associated with increased risk of lung cancer. Respiratory conditions often co-occur and few studies have investigated multiple conditions simultaneously. Objectives: Investigate lung cancer risk associated with chronic bronchitis, emphysema, tuberculosis, pneumonia and asthma. Methods and Measurements: The SYNERGY project pooled information on previous respiratory diseases from 12,739 cases and 14,945 controls from 7 case-control studies conducted in Europe and Canada. Multivariate logistic regression models were used to investigate the relationship between individual diseases adjusting for co-occurring conditions, and patterns of respiratory disease diagnoses and lung cancer. Analyses were stratified by sex, and adjusted for age, centre, ever-employed in a high-risk occupation, education, smoking status, cigarette pack-years and time-since quitting smoking. Main Results: Chronic bronchitis and emphysema were positively associated with lung cancer, after accounting for other respiratory diseases and smoking (for example in men OR=1.33; 95% CI 1.20-1.48 and 1.50; 1.21-1.87, respectively). A positive relationship was observed between lung cancer and pneumonia diagnosed 2 or fewer years prior to lung cancer (OR=3.31; 2.33-4.70 for men), but not longer. Co-occurrence of chronic bronchitis, emphysema and pneumonia had a stronger positive association with lung cancer than individual conditions. Asthma had an inverse association with lung cancer, the association being stronger with an asthma diagnosis 5 or more years prior to lung cancer compared to shorter. Conclusions: Findings from this large international case-control consortium indicate that after accounting for co-occurring respiratory diseases, chronic bronchitis and emphysema continue to have a positive association with lung cancer.
Rachel Denholm; Joachim Schüz; Kurt Straif; Isabelle Stücker; Karl-Heinz Jöckel; Darren R Brenner; Sara De Matteis; Paolo Boffetta; Florence Guida; Irene Brüske; Heinz-Erich Wichmann; Maria Teresa Landi; Neil Caporaso; Jack Siemiatycki; Wolfgang Ahrens; Hermann Pohlabeln; David Zaridze; John K Field; John McLaughlin; Paul Demers; Neonila Szeszenia-Dabrowska; Jolanta Lissowska; Peter Rudnai; Eleonora Fabianova; Rodica Stanescu Dumitru; Vladimir Bencko; Lenka Foretova; Vladimir Janout; Benjamin Kendzia; Susan Peters; Thomas Behrens; Roel Vermeulen; Thomas Brüning; Hans Kromhout; Ann Olsson
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-7-23
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  -     ISSN:  1535-4970     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-7-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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