| Previable rupture of membranes: effect of amniotic fluid on pregnancy outcome. | |
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MedLine Citation:
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PMID: 17920752 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate pregnancy outcome and the role of the amount of amniotic fluid (AF) in the prognosis of extremely preterm (<24 weeks) premature rupture of membranes (EPPROM). STUDY DESIGN: Women with EPPROM and on-going pregnancy after 1 week of expectant management were included. Exclusion criteria: fetal anomalies, termination of pregnancy and spontaneous recovery of AF within the first week. The effect of the large vertical pocket (LVP) on pregnancy outcome was assessed by a Cox regression model which included three covariates: LVP measurements from rupture to 24 weeks, gestational age at rupture of membranes and sealing procedure. RESULTS: Thirty-seven women were included in the study. The overall survival rate after the neonatal period was 40.5% (15/37) which increased to 62.5% (15/24) in neonates born alive after 24 weeks of gestation. Mean and S.D. of gestational age at rupture of membranes were 19.0 (+/-3.8) weeks. From rupture to 24 weeks, the pooled mean and standard deviation of LVP were 20.5 (+/-15.4)mm. Multivariate analysis showed that the likelihood for neonate survival increased by 2.7 (95% CI 1.45-4.65) for each 5mm of LVP during the follow-up from rupture to 24 weeks. After controlling for AF amount, neither the gestational age at rupture nor the sealing procedure showed any significant effect on pregnancy outcome. CONCLUSION: Although the prognosis of EPPROM is poor overall, survival improves as the amount of AF before 24 weeks increases. |
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Authors:
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Montse Palacio; Teresa Cobo; Francesc Figueras; Olga Gómez; Oriol Coll; Vicenç Cararach; Eduard Gratacós |
Publication Detail:
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Type: Journal Article Date: 2007-10-24 |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 138 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-02 Completed Date: 2008-10-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 158-63 Citation Subset: IM |
Affiliation:
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Department of Maternal-Fetal Medicine, Hospital Clínic de Barcelona, Sabino de Arana 1, Spain. mpalacio@clinic.ub.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amniotic Fluid / physiology* Female Fetal Death / etiology* Fetal Membranes, Premature Rupture / physiopathology* Humans Multivariate Analysis Pregnancy Pregnancy Outcome ROC Curve Regression Analysis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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