Document Detail


Preventive role of exercise training in autonomic, hemodynamic, and metabolic parameters in rats under high risk of metabolic syndrome development.
MedLine Citation:
PMID:  23329818     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
High fructose consumption contributes to metabolic syndrome incidence, whereas exercise training promotes several beneficial adaptations. In this study, we demonstrated the preventive role of exercise training in the metabolic syndrome derangements in a rat model. Wistar rats receiving fructose overload in drinking water (100 g/l) were concomitantly trained on a treadmill (FT) or kept sedentary (F) for 10 wk. Control rats treated with normal water were also submitted to exercise training (CT) or sedentarism (C). Metabolic evaluations consisted of the Lee index and glycemia and insulin tolerance test (kITT). Blood pressure (BP) was directly measured, whereas heart rate (HR) and BP variabilities were evaluated in time and frequency domains. Renal sympathetic nerve activity was also recorded. F rats presented significant alterations compared with all the other groups in insulin resistance (in mg · dl(-1) · min(-1): F: 3.4 ± 0.2; C: 4.7 ± 0.2; CT: 5.0 ± 0.5 FT: 4.6 ± 0.4), mean BP (in mmHG: F: 117 ± 2; C: 100 ± 2; CT: 98 ± 2; FT: 105 ± 2), and Lee index (in g/mm: F = 0.31 ± 0.001; C = 0.29 ± 0.001; CT = 0.27 ± 0.002; FT = 0.28 ± 0.002), confirming the metabolic syndrome diagnosis. Exercise training blunted all these derangements. Additionally, FS group presented autonomic dysfunction in relation to the others, as seen by an ≈ 50% decrease in baroreflex sensitivity and 24% in HR variability, and increases in sympathovagal balance (140%) and in renal sympathetic nerve activity (45%). These impairments were not observed in FT group, as well as in C and CT. Correlation analysis showed that both Lee index and kITT were associated with vagal impairment caused by fructose. Therefore, exercise training plays a preventive role in both autonomic and hemodynamic alterations related to the excessive fructose consumption.
Authors:
Ivana Cinthya Moraes-Silva; Cristiano Mostarda; Edson Dias Moreira; Kleiton Augusto Santos Silva; Fernando dos Santos; Kátia de Angelis; Vera de Moura Azevedo Farah; Maria Claudia Irigoyen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-17
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  114     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-18     Completed Date:  2013-09-05     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  786-91     Citation Subset:  IM    
Affiliation:
Hypertension Unit, Heart Institute (InCor University of Sao Paulo Medical School, Sao Paulo, Brazil. ivanacms.incor@usp.br
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MeSH Terms
Descriptor/Qualifier:
Animals
Autonomic Nervous System / physiopathology*
Baroreflex*
Biological Markers / blood
Blood Glucose / metabolism
Blood Pressure
Disease Models, Animal
Energy Metabolism*
Fructose
Heart Rate
Hemodynamics*
Insulin / blood
Insulin Resistance
Kidney / innervation*
Male
Metabolic Syndrome X / blood,  chemically induced,  diagnosis,  physiopathology,  prevention & control*
Physical Exertion*
Rats
Rats, Wistar
Running
Sedentary Lifestyle
Time Factors
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Blood Glucose; 0/Insulin; 30237-26-4/Fructose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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