Document Detail

Preventive role of exercise training in autonomic, hemodynamic, and metabolic parameters in rats under high risk of metabolic syndrome development.
MedLine Citation:
PMID:  23329818     Owner:  NLM     Status:  MEDLINE    
High fructose consumption contributes to metabolic syndrome incidence, whereas exercise training promotes several beneficial adaptations. In this study, we demonstrated the preventive role of exercise training in the metabolic syndrome derangements in a rat model. Wistar rats receiving fructose overload in drinking water (100 g/l) were concomitantly trained on a treadmill (FT) or kept sedentary (F) for 10 wk. Control rats treated with normal water were also submitted to exercise training (CT) or sedentarism (C). Metabolic evaluations consisted of the Lee index and glycemia and insulin tolerance test (kITT). Blood pressure (BP) was directly measured, whereas heart rate (HR) and BP variabilities were evaluated in time and frequency domains. Renal sympathetic nerve activity was also recorded. F rats presented significant alterations compared with all the other groups in insulin resistance (in mg · dl(-1) · min(-1): F: 3.4 ± 0.2; C: 4.7 ± 0.2; CT: 5.0 ± 0.5 FT: 4.6 ± 0.4), mean BP (in mmHG: F: 117 ± 2; C: 100 ± 2; CT: 98 ± 2; FT: 105 ± 2), and Lee index (in g/mm: F = 0.31 ± 0.001; C = 0.29 ± 0.001; CT = 0.27 ± 0.002; FT = 0.28 ± 0.002), confirming the metabolic syndrome diagnosis. Exercise training blunted all these derangements. Additionally, FS group presented autonomic dysfunction in relation to the others, as seen by an ≈ 50% decrease in baroreflex sensitivity and 24% in HR variability, and increases in sympathovagal balance (140%) and in renal sympathetic nerve activity (45%). These impairments were not observed in FT group, as well as in C and CT. Correlation analysis showed that both Lee index and kITT were associated with vagal impairment caused by fructose. Therefore, exercise training plays a preventive role in both autonomic and hemodynamic alterations related to the excessive fructose consumption.
Ivana Cinthya Moraes-Silva; Cristiano Mostarda; Edson Dias Moreira; Kleiton Augusto Santos Silva; Fernando dos Santos; Kátia de Angelis; Vera de Moura Azevedo Farah; Maria Claudia Irigoyen
Related Documents :
8576868 - A study of the role of corticosterone as a mediator in exercise-induced stimulation of ...
20967198 - Lipidomics analysis reveals efficient storage of hepatic triacylglycerides enriched in ...
23823148 - Sex and vasodilator responses to hypoxia at rest and during exercise.
11673518 - C57bl/6 and balb/c bronchoalveolar macrophages respond differently to exercise.
22117018 - Asthma in adolescent athletes.
15919108 - Effect of methyl-beta-cyclodextrin treatment of pig spermatozoa on in vitro fertilizati...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-17
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  114     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-18     Completed Date:  2013-09-05     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  786-91     Citation Subset:  IM    
Hypertension Unit, Heart Institute (InCor University of Sao Paulo Medical School, Sao Paulo, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Autonomic Nervous System / physiopathology*
Biological Markers / blood
Blood Glucose / metabolism
Blood Pressure
Disease Models, Animal
Energy Metabolism*
Heart Rate
Insulin / blood
Insulin Resistance
Kidney / innervation*
Metabolic Syndrome X / blood,  chemically induced,  diagnosis,  physiopathology,  prevention & control*
Physical Exertion*
Rats, Wistar
Sedentary Lifestyle
Time Factors
Reg. No./Substance:
0/Biological Markers; 0/Blood Glucose; 0/Insulin; 30237-26-4/Fructose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Neuromotor Control in Chronic Obstructive Pulmonary Diseas.
Next Document:  Separating in vivo mechanical stimuli for postpneumonectomy compensation: imaging and ultrastructura...