| Preventive role of exercise training in autonomic, hemodynamic and metabolic parameters in rats under high risk of metabolic syndrome development. | |
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MedLine Citation:
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PMID: 23329818 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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High fructose consumption contributes to metabolic syndrome incidence while exercise training promotes several beneficial adaptations. In this study, we demonstrated the preventive role of exercise training in the metabolic syndrome derangements in a rat model. Wistar rats receiving fructose overload in drinking water (100g/l) were concomitantly trained on a treadmill (FT) or kept sedentary (F) for 10 weeks. Control rats treated with normal water were also submitted to exercise training (CT) or sedentarism (C). Metabolic evaluations consisted of the Lee index, glycemia and insulin tolerance test (kITT). Blood pressure (BP) was directly measured while heart rate (HR) and BP variabilities were evaluated in time and frequency domains. Renal sympathetic nerve activity was also recorded. F rats presented significant alterations when compared to all the other groups in insulin resistance (F:3.4±0.2; C:4.7±0.2; CT: 5.0±0.5 FT: 4.6±0.4 mg/dl/min), mean BP (F:117±2; C:100±2; CT:98±2; FT:105±2mmHg) and Lee index (F=0.31±0.001; C=0.29±0.001; CT=0.27±0.002; FT=0.28±0.002 g/mm), confirming the metabolic syndrome diagnosis. Exercise training blunted all these derangements. Additionally, FS group presented autonomic dysfunction in relation to the others, as seen by an approximate 50% decrease in baroreflex sensitivity and 24% in HR variability, and increases in sympathovagal balance (140%) and in renal sympathetic nerve activity (45%). These impairments were not observed in FT group, as well in C and CT. Correlation analysis showed that both Lee index and kITT were associated with vagal impairment caused by fructose. Therefore, exercise training plays a preventive role in both autonomic and hemodynamic alterations related to the excessive fructose consumption. |
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Authors:
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Ivana Cinthya Moraes-Silva; Cristiano Teixeira Mostarda; Edson Dias Moreira; Kleiton Augusto Santos Silva; Fernando Dos Santos; Katia De Angelis; Vera de Moura Azevedo Farah; Maria Claudia Irigoyen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-17 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Heart Institute (InCorFMUSP University of Sao Paulo. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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