Document Detail

Preventive and improvement effects of exercise training and supplement intake in white adipose tissues on obesity and lifestyle-related diseases.
MedLine Citation:
PMID:  22362099     Owner:  NLM     Status:  MEDLINE    
Recent increases in the number of obese individuals and individuals suffering from lifestyle-related diseases, such as type 2 diabetes, that accompany obesity have become a serious social problem. White adipose tissue (WAT) is more than a mere organ for storage of energy; it is also a highly active metabolic and endocrine organ that secretes physiologically active substances collectively known as adipokines, including tumor necrosis factor-α and adiponectin. Dysregulated expression of adipokines in WAT that is hypertrophied by obesity has been closely associated with the phenomenon of insulin resistance. Therefore, WAT is currently considered to be one of the tissues that promote lifestyle-related diseases. Reduction of excess WAT that results from obesity is seen as an important strategy in preventing and improving lifestyle-related diseases. This review shows that exercise training as well as intake of supplements, such as polyphenols, is one strategy for this, because this regimen can result in reduction of WAT mass, which affects the expression and secretory response of adipokines.
Takuya Sakurai; Junetsu Ogasawara; Takako Kizaki; Yoshinaga Ishibashi; Yoshikazu Sumitani; Kazuto Takahashi; Hitoshi Ishida; Hiromi Miyazaki; Daizoh Saitoh; Shukoh Haga; Tetsuya Izawa; Hideki Ohno
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-02-24
Journal Detail:
Title:  Environmental health and preventive medicine     Volume:  17     ISSN:  1347-4715     ISO Abbreviation:  Environ Health Prev Med     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-10     Completed Date:  2013-01-23     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  9609642     Medline TA:  Environ Health Prev Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  348-56     Citation Subset:  IM    
Department of Molecular Predictive Medicine and Sport Science, School of Medicine, Kyorin University, Shinkawa, Mitaka, Tokyo, Japan.
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MeSH Terms
Adiponectin / metabolism*
Adipose Tissue, White / drug effects,  immunology,  metabolism*
Chemokine CCL2 / metabolism
Dietary Supplements*
Life Style*
Obesity / immunology,  metabolism,  prevention & control*,  therapy
Polyphenols / administration & dosage
Tumor Necrosis Factor-alpha / metabolism
Reg. No./Substance:
0/ADIPOQ protein, human; 0/Adiponectin; 0/Chemokine CCL2; 0/Polyphenols; 0/Tumor Necrosis Factor-alpha

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