| Preventive effects of a traditional Chinese formulation, Chaihu-jia-Longgu-Muli-tang, on intimal thickening of carotid artery injured by balloon endothelial denudation in rats. | |
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MedLine Citation:
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PMID: 11999136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report here that the traditional Chinese formulation, Chaihu-jia-Longgu-Muli-tang (CLM), significantly inhibited the increase in intimal thickening in rat carotid artery injured by balloon endothelial denudation, which mimics many aspects of restenosis after percutaneous coronary intervention (PCI) in humans. CLM, Saiko-ka-Ryukotsu-Borei-to in Japanese, is commonly prescribed for symptoms accompanying hypertension and atherosclerosis in Japanese Kampo medical care. CLM administered orally 1 week before and 1, 4 and 8 weeks after balloon injury inhibited the increase in intimal area, intimal/medial ratio and stenosis ratio. To our knowledge, this is the first report demonstrating inhibitory effects of a traditional Chinese formulation on intimal thickening of carotid artery after balloon injury. It is worth noting that CLM maintained its inhibitory effect up to 8 weeks after balloon injury. The reduction in intimal thickening by CLM could have resulted from inhibition of intimal smooth muscle cell proliferation, which was assessed by immuno-histochemical analysis using monoclonal antibody against proliferating cell nuclear antigen. Therefore, CLM may be a favourable candidate for prevention of restenosis after PCI. Moreover CLM may have a therapeutic value in the prevention of atherosclerosis, because restenosis after PCI is considered to be an accelerated atherosclerosis. |
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Authors:
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Dong-Wook Kim; Hwa-Jin Chung; Katsuya Nose; Ikuro Maruyama; Tadato Tani |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The Journal of pharmacy and pharmacology Volume: 54 ISSN: 0022-3573 ISO Abbreviation: J. Pharm. Pharmacol. Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-05-09 Completed Date: 2002-11-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376363 Medline TA: J Pharm Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 571-5 Citation Subset: IM |
Affiliation:
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Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary
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adverse effects* Animals Anthranilic Acids / pharmacology, therapeutic use Body Weight / drug effects Carotid Artery Injuries / drug therapy*, etiology Carotid Stenosis / prevention & control* Cell Division / drug effects Drugs, Chinese Herbal / chemistry, pharmacology*, therapeutic use Eating / drug effects Endothelium, Vascular / drug effects*, injuries, pathology Humans Hyperplasia / drug therapy, prevention & control Immunohistochemistry Male Medicine, Chinese Traditional Medicine, Kampo Molecular Structure Muscle, Smooth, Vascular / cytology, drug effects, metabolism Platelet Aggregation Inhibitors / pharmacology, therapeutic use Postoperative Complications / drug therapy, prevention & control Proliferating Cell Nuclear Antigen / analysis Rats Rats, Wistar Tunica Intima / drug effects, injuries, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Anthranilic Acids; 0/Drugs, Chinese Herbal; 0/Platelet Aggregation Inhibitors; 0/Proliferating Cell Nuclear Antigen; 0/TW 001; 0/saiko-ka-ryukotsu-borei-to; 53902-12-8/tranilast |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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