Document Detail

Preventive effects of rebamipide on NSAID-induced gastric mucosal injury and reduction of gastric mucosal blood flow in healthy volunteers.
MedLine Citation:
PMID:  17410467     Owner:  NLM     Status:  MEDLINE    
The precise mechanisms of acute damage and the role of gastric mucosal blood flow in gastric mucosal injury induced by nonsteroidal anti-inflammatory drugs (NSAIDs) remain uncertain. The aim of this study was to evaluate the preventive effect of rebamipide on gastric mucosal injury and reduction of gastric mucosal blood flow (GMBF) after ibuprofen administration. Twenty healthy volunteers were randomized two groups. The rebamipide group took ibuprofen, 1800 mg/day, and rebamipide, 100 mg t.i.d., for 7 days. The placebo group took ibuprofen, 1800 mg/day. The numbers of gastric ulcer subjects were three in the placebo group and zero in the rebamipide group. The mean modified Lanza score after ibuprofen administration was significantly higher in the placebo group than the rebamipide group (2.9+/-1.7 vs. 1.3+/-1.0, respectively; P=0.032). The GMBF of the placebo group was significantly decreased at antrum from baseline, from 2.8+/-0.5 to 2.0+/-0.5 tissue perfusion units (P=0.005). There was no difference in GMBF change in the rebamipide group. Gastric mucosal injury was correlated with GMBF reduction in antrum (r=-0.677, P=0.001). In conclusion, it is suggested that the decrease in GMBF may have been associated with NSAID-induced gastric mucosal injury, and rebamipide may have prevented NSIAD-induced gastric mucosal injury by maintaining GMBF in healthy subjects.
Hyung-Keun Kim; Jin-Il Kim; Jae-Kwang Kim; Joon-Yeol Han; Soo-Heon Park; Kyu-Yong Choi; In-Sik Chung
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2007-04-05
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  52     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-06-28     Completed Date:  2007-08-31     Revised Date:  2007-10-19    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1776-82     Citation Subset:  AIM; IM    
Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, and Uijeongbu St. Mary's Hospital, Uijeongbu City, Korea.
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MeSH Terms
Alanine / analogs & derivatives*,  therapeutic use
Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
Anti-Ulcer Agents / therapeutic use*
Gastric Mucosa / blood supply*,  drug effects*
Ibuprofen / adverse effects
Middle Aged
Quinolones / therapeutic use*
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Anti-Ulcer Agents; 0/Quinolones; 111911-87-6/rebamipide; 15687-27-1/Ibuprofen; 56-41-7/Alanine

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