Document Detail

Preventive effects of phylloquinone on hemorrhagic death induced by butylated hydroxytoluene in male rats.
MedLine Citation:
PMID:  430246     Owner:  NLM     Status:  MEDLINE    
The effects of vitamin K on hemorrhagic death induced by dietary butylated hydroxytoluene (BHT) were studied. Male Sprague-Dawley rats were given BHT or two phenolic antioxidants (2,4,6-tri-tert-butylphenol and 2,5-di-tert-butylhydroquinone) in combination with a 24% casein basal diet. The levels of the phenols were chosen to nearly equal LD50 (40 days). Hemorrhagic death, hemorrhage and a decrease in prothrombin index caused by 1.20% BHT were prevented by simultaneously adding phylloquinone (0.68 mumole/kg/day). Phylloquinone also inhibited the effect of the related phenolic antioxidants. Ten nanomoles of phylloquinone injected into the femoral vein on day 3 of feeding 1.2% BHT increased the prothrombin concentration from 28% of normal to 100% of normal within 18 to 24 hours. Phylloquinone oxide also prevented hypoprothrombinemia due to BHT. These results suggest that BHT-induced hemorrhagic death may be caused by direct and/or indirect vitamin K deficiency, and its mechanism may be different from those of warfarin.
O Takahashi; K Hiraga
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of nutrition     Volume:  109     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  1979 Mar 
Date Detail:
Created Date:  1979-06-29     Completed Date:  1979-06-29     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  453-7     Citation Subset:  IM    
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MeSH Terms
Butylated Hydroxytoluene*
Dose-Response Relationship, Drug
Hemorrhage / chemically induced,  mortality,  prevention & control*
Hypoprothrombinemias / chemically induced,  prevention & control
Injections, Intravenous
Prothrombin Time
Vitamin K 1 / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Antioxidants; 0/Cresols; 0/Hydroquinones; 0/Phenols; 128-37-0/Butylated Hydroxytoluene; 84-80-0/Vitamin K 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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