| Preventive effects of low molecular mass potassium alginate extracted from brown algae on DOCA salt-induced hypertension in rats. | |
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MedLine Citation:
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PMID: 19932586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Available evidence indicates that brown algae may be beneficial for the treatment of high blood pressure. Our recent study demonstrated that low molecular mass potassium alginate (L-PA), one of the major polysaccharides extracted from brown algae, decreased systolic blood pressure (SBP) in spontaneous hypertensive rats. The present study investigated the effects of L-PA on deoxycorticosterone acetate (DOCA) salt-induced hypertension in rats. Hypertension was induced by biweekly subcutaneous injections of 50mg/kg DOCA plus 1% NaCl in drinking water. The control group received saline injections. L-PA (250 or 500 mg/kg), KCl (239 mg/kg), or volume-matched solvent was administered orally once daily for 30 days. DOCA salt administration significantly increased SBP, sodium excretion, serum sodium content, circulating plasma volume (CPV), plasma atrial natriuretic peptide (ANP) content, heart and renal weight indices, and mortality and decreased plasma aldosterone (ALD) and serum potassium levels in the vehicle-treated DOCA salt group compared with the control group. However, L-PA dose-dependently normalized the above changes induced by DOCA salt, with the exception of further increasing sodium excretion, while KCl did not affect the changes caused by DOCA salt, with the exception of slightly ameliorating hypokalemia and mortality. These findings suggest that L-PA may offer a novel form of potassium supplementation with greater antihypertensive and sodium excretion actions than KCl and may likely be beneficial for the primary prevention and treatment of hypertension and its cardiovascular sequelae. |
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Authors:
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Yu-Yun Chen; Wei Ji; Jun-Rong Du; Dong-Ke Yu; Yao He; Chuan-Xing Yu; De-Shan Li; Chang-yi Zhao; Kui-yun Qiao |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2009-10-27 |
Journal Detail:
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Title: Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie Volume: 64 ISSN: 1950-6007 ISO Abbreviation: Biomed. Pharmacother. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-27 Completed Date: 2010-07-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8213295 Medline TA: Biomed Pharmacother Country: France |
Other Details:
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Languages: eng Pagination: 291-5 Citation Subset: IM |
Copyright Information:
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(c) 2009 Elsevier Masson SAS. All rights reserved. |
Affiliation:
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Department of Pharmacology & Biopharmaceutics, Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, People's Republic of China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algae, Brown
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chemistry* Alginates / administration & dosage, isolation & purification, pharmacology* Animals Antihypertensive Agents / administration & dosage, isolation & purification, pharmacology* Blood Pressure / drug effects Desoxycorticosterone Disease Models, Animal Dose-Response Relationship, Drug Glucuronic Acid / administration & dosage, isolation & purification, pharmacology Hexuronic Acids / administration & dosage, isolation & purification, pharmacology Hypertension / drug therapy*, physiopathology Male Potassium / metabolism Potassium Chloride / pharmacology Rats Rats, Sprague-Dawley Sodium / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Alginates; 0/Antihypertensive Agents; 0/Hexuronic Acids; 576-37-4/Glucuronic Acid; 64-85-7/Desoxycorticosterone; 7440-09-7/Potassium; 7440-23-5/Sodium; 7447-40-7/Potassium Chloride; 9005-32-7/alginic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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