| Preventive effects of glycyrrhizin on estrogen-related endometrial carcinogenesis in mice. | |
| | |
MedLine Citation:
|
PMID: 17273742 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We have previously reported on the inhibitory effect of Glycyrrhizae radix (Gl radix) on mouse endometrial carcinogenesis. The present study was performed to clarify the effects of Gl radix and glycyrrhizin (GL), the main part of Gl radix, on estradiol (E2)-related endometrial carcinogenesis. Both Gl radix and GL exerted a significant decrease in the COX-2, IL-1alpha and TNF-alpha mRNA expressions. GL generated a significant decrease in the incidence of endometrial adenocarcinoma. Accordingly, the preventive effects of Gl radix may be attributable to GL, thus being related with the suppression of COX-2, IL-1alpha and TNF-alpha. Gl radix and GL could therefore be a promising formula for the chemoprevention of human endometrial cancer. |
| | |
Authors:
|
Kenji Niwa; Zenglin Lian; Kyoko Onogi; Wu Yun; Liulin Tang; Hideki Mori; Teruhiko Tamaya |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Oncology reports Volume: 17 ISSN: 1021-335X ISO Abbreviation: Oncol. Rep. Publication Date: 2007 Mar |
Date Detail:
|
Created Date: 2007-02-02 Completed Date: 2007-05-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9422756 Medline TA: Oncol Rep Country: Greece |
Other Details:
|
Languages: eng Pagination: 617-22 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Gifu 501-1194, Japan. kniwa@gifu-u.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antineoplastic Agents / therapeutic use* Cyclooxygenase 1 / drug effects Cyclooxygenase 2 / drug effects Endometrial Neoplasms / metabolism, prevention & control* Estrogens / metabolism Female Glycyrrhiza / chemistry* Glycyrrhizic Acid / therapeutic use* Immunohistochemistry Interleukin-1alpha / metabolism Mice Mice, Inbred ICR Neoplasms, Hormone-Dependent / prevention & control* Ovariectomy Plant Extracts / therapeutic use* RNA, Messenger / drug effects Reverse Transcriptase Polymerase Chain Reaction Tumor Necrosis Factor-alpha / drug effects |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents; 0/Estrogens; 0/Interleukin-1alpha; 0/Plant Extracts; 0/RNA, Messenger; 0/Tumor Necrosis Factor-alpha; 1405-86-3/Glycyrrhizic Acid; EC 1.14.99.1/Cyclooxygenase 1; EC 1.14.99.1/Cyclooxygenase 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: S-phase reduction in T47D human breast cancer epithelial cells induced by an S100P antisense-retrovi...
Next Document: Clinical significance of RCAS1 as a biomarker of ovarian cancer.