Document Detail

Preventive effect of taurine against acute paraquat intoxication in beagles.
MedLine Citation:
PMID:  2770058     Owner:  NLM     Status:  MEDLINE    
The continuous infusion of taurine markedly protected against paraquat (PQ)-induced oliguria in beagles. Pharmacokinetic studies revealed that taurine infusion increased the blood concentration of PQ and reduced the net content in the kidney and, to a lesser extent, in the lung. The excretion of PQ into the urine was unaltered. The infusion of glycine did not have such effects.
K Izumi; R Nagata; T Motoya; J Yamashita; T Hirokane; T Nagata; Y Satoh; Y Sawada; M Ishibashi; H Yoshida
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese journal of pharmacology     Volume:  50     ISSN:  0021-5198     ISO Abbreviation:  Jpn. J. Pharmacol.     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-09-28     Completed Date:  1989-09-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2983305R     Medline TA:  Jpn J Pharmacol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  229-33     Citation Subset:  IM    
Department of Pharmacology, Faculty of Medicine, Kagoshima University, Japan.
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MeSH Terms
Infusions, Intravenous
Lung / drug effects,  metabolism
Paraquat / administration & dosage,  antagonists & inhibitors*,  toxicity
Taurine / pharmacology*
Urodynamics / drug effects
Reg. No./Substance:
107-35-7/Taurine; 4685-14-7/Paraquat

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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