Document Detail

Preventive effect of simultaneously infused lipid emulsion against thrombophlebitis during postoperative peripheral parenteral nutrition.
MedLine Citation:
PMID:  8520158     Owner:  NLM     Status:  MEDLINE    
A prospective, randomized study was conducted to determine whether simultaneous infusion of lipid emulsion with an amino acid-dextrose-electrolyte solution would reduce the incidence of thrombophlebitis (TP) during postoperative peripheral parenteral nutrition (PPN). Thirty patients who had undergone gastric resection for adenocarcinoma were randomly divided into two groups according to whether they were infused with 10% lipid emulsion (group A) or 5% glucose solution (group B) simultaneously with the amino acid-glucose solutions. The total osmolarity of the infusion solutions in each group was 853 mOsm/l. The incidence of complications due to TP, namely, redness and/or edema beneath the cannula insertion site and/or pain, was investigated. There were no differences in the background characteristics of the patients in groups A and B, except regarding concurrent resection of other organs (P = 0.03). The incidence of edema in group A was significantly lower than in group B on postoperative days 2 and 4, although there was no difference in the incidence of redness and pain between the two groups. These findings suggest that the simultaneous infusion of lipid emulsion has a preventive effect against TP during postoperative PPN, and may be a practical means of providing PPN after gastrointestinal surgery.
S Matsusue; S Nishimura; S Koizumi; T Nakamura; H Takeda
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Surgery today     Volume:  25     ISSN:  0941-1291     ISO Abbreviation:  Surg. Today     Publication Date:  1995  
Date Detail:
Created Date:  1996-01-24     Completed Date:  1996-01-24     Revised Date:  2006-08-03    
Medline Journal Info:
Nlm Unique ID:  9204360     Medline TA:  Surg Today     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  667-71     Citation Subset:  IM    
Department of Abdominal Surgery, Tenri Hospital, Nara, Japan.
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MeSH Terms
Adenocarcinoma / surgery
Edema / etiology,  prevention & control
Fat Emulsions, Intravenous / administration & dosage,  therapeutic use*
Middle Aged
Osmolar Concentration
Parenteral Nutrition, Total / adverse effects*
Postoperative Care* / methods
Prospective Studies
Stomach Neoplasms / surgery
Thrombophlebitis / etiology,  prevention & control*
Reg. No./Substance:
0/Fat Emulsions, Intravenous

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