| Preventive effect of recombinant human lactoferrin in a rabbit preterm delivery model. | |
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MedLine Citation:
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PMID: 15846177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Lactoferrin, an iron-binding glycoprotein found in cervical mucus and amniotic fluid, plays a defensive role against mucosal infections. This study examined the effect of recombinant human lactoferrin on preterm delivery in a rabbit model. STUDY DESIGN: Anesthetized rabbits were randomly assigned to receive either inoculation with Escherichia coli or saline solution and to receive treatment with or without recombinant human lactoferrin inserted into the cervix 2 hours before bacterial inoculation (condition A: saline + saline; condition B: E coli + saline; condition C: E coli + recombinant human lactoferrin). E coli , saline solution, and recombinant human lactoferrin were inserted into the cervix using a hysteroscope and a sterile polyethylene cannula. Fetus survival rate and days to delivery after inoculation were monitored and tumor necrosis factor-alpha concentrations were measured in maternal serum and amniotic fluid. RESULTS: Fetus survival for conditions A, B, and C were 95.7%, 0%, and 32.6%, respectively, whereas pregnancy continuation was 7.00 +/- 0 days, 3.25 +/- 0.43 days, and 4.85 +/- 1.77 days, respectively. CONCLUSION: Cervical recombinant human lactoferrin administration increased fetal survival and extended pregnancy. Lactoferrin has an anti-inflammatory action as well as an antibacterial action, suggesting that recombinant human lactoferrin has the potential to prevent preterm delivery originating from cervical infection in the clinical setting. |
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Authors:
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Akitoshi Hasegawa; Katsufumi Otsuki; Yasushi Sasaki; Maki Sawada; Kaori Mitsukawa; Hiroshi Chiba; Masaaki Nagatsuka; Takashi Okai; Atsuko Kato |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 192 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-04-22 Completed Date: 2005-05-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 1038-43 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, Showa University, School of Medicine, Tokyo, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal Escherichia coli Infections / drug therapy* Female Fetal Death Fetal Membranes, Premature Rupture / prevention & control Humans Immunohistochemistry Lactoferrin / pharmacology* Obstetric Labor, Premature / prevention & control* Placenta / pathology Pregnancy Pregnancy, Animal* Primary Prevention / methods* Rabbits Random Allocation Recombinant Proteins Reference Values Sensitivity and Specificity Tumor Necrosis Factor-alpha / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Lactoferrin; 0/Recombinant Proteins; 0/Tumor Necrosis Factor-alpha |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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