Document Detail

Preventive effect of phosphoenolpyruvate on hypoxemia induced by oleic acid in Guinea pigs.
MedLine Citation:
PMID:  12612443     Owner:  NLM     Status:  MEDLINE    
Oleic acid-induced hypoxemia is an animal model of acute respiratory distress syndrome (ARDS). Increased capillary permeability is a cause of hypoxemia in lung injury. Endothelial cells form a major capillary barrier, and disruption of the barrier appears to involve a decreased level of ATP in the cells. Phosphoenolpyruvate (PEP) is an endogenous substance that is one of the ATP precursors and can cross some cell membranes via anion exchanger. We examined the effect of PEP on oleic acid-induced lung injury in guinea pigs. An intravenous injection of oleic acid (15 microl/kg) caused severe hypoxemia. Pretreatment with PEP at a dose of 2, 20, or 200 micromol/kg attenuated the oleic acid-induced decrease in the arterial partial pressure of oxygen in a dose-dependent manner. Furthermore, PEP attenuated the oleic acid-induced increase in vascular permeability in the proximal and distal bronchi, as indicated by the extravascular leakage of Evans Blue dye. The combination of PEP with ATP (4 micromol/kg) showed no additional inhibitory effect on oleic acid-induced lung injury, compared with PEP alone. We suggest that PEP is a promising candidate to prevent hypoxemia in acute lung injuries associated with increased vascular permeability, such as ARDS.
Saeid Golbidi; Hiroshi Moriuchi; Changqing Yang; Mitsuru Irikura; Tetsumi Irie; Naotaka Hamasaki
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  26     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-03     Completed Date:  2003-11-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  336-40     Citation Subset:  IM    
Department of Physiology and Pharmacology, Kashan University of Medical Sciences, Iran.
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MeSH Terms
Anoxia / chemically induced,  prevention & control*
Blood Gas Analysis / methods
Capillary Permeability / drug effects
Carbon Dioxide / metabolism
Coloring Agents / pharmacokinetics
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Interactions
Evans Blue / pharmacokinetics
Guinea Pigs
Hydrogen-Ion Concentration / drug effects
Lung / drug effects
Oleic Acid*
Oxygen / metabolism
Phosphoenolpyruvate / therapeutic use*
Random Allocation
Respiratory Distress Syndrome, Adult / complications,  drug therapy*
Time Factors
Vascular Resistance
Reg. No./Substance:
0/Coloring Agents; 112-80-1/Oleic Acid; 124-38-9/Carbon Dioxide; 314-13-6/Evans Blue; 73-89-2/Phosphoenolpyruvate; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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