Document Detail


Preventive effect of manidipine on severe hypertension and proteinuria induced by the inhibition of endothelial-derived relaxation factor formation in stroke-prone spontaneously hypertensive rats.
MedLine Citation:
PMID:  1343297     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of a calcium antagonist, manidipine, on blood pressure and proteinuria induced by the inhibition of endothelial-derived relaxation factor (EDRF) formation was examined. Manidipine attenuated the increase in blood pressure and prevented proteinuria caused by renal damage associated with the inhibition of EDRF formation in stroke-prone spontaneously hypertensive rat (SHRSP) and Wistar Kyoto (WKY) rats.
Authors:
Y Nara; K Ikeda; Y Yamori
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Blood pressure. Supplement     Volume:  3     ISSN:  0803-8023     ISO Abbreviation:  Blood Press Suppl     Publication Date:  1992  
Date Detail:
Created Date:  1994-03-08     Completed Date:  1994-03-08     Revised Date:  2008-02-26    
Medline Journal Info:
Nlm Unique ID:  9300787     Medline TA:  Blood Press Suppl     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  85-6     Citation Subset:  IM    
Affiliation:
Department of Pathology, Shimane Medical University, Izumo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arginine / analogs & derivatives,  antagonists & inhibitors,  pharmacology
Blood Pressure / drug effects
Calcium Channel Blockers / therapeutic use*
Cerebrovascular Disorders / etiology,  metabolism*
Dihydropyridines / therapeutic use*
Hypertension / metabolism*,  prevention & control*
Male
Nitric Oxide / antagonists & inhibitors,  biosynthesis*
Nitroarginine
Proteinuria / metabolism,  prevention & control*
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Dihydropyridines; 10102-43-9/Nitric Oxide; 2149-70-4/Nitroarginine; 74-79-3/Arginine; 89226-50-6/manidipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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