Document Detail


Preventive effect of hydrolyzed infant formulas persists until age 6 years: long-term results from the German Infant Nutritional Intervention Study (GINI).
MedLine Citation:
PMID:  18539195     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The long-term effect of nutritional intervention with hydrolyzed infant formulas on allergy development has not been sufficiently evaluated. OBJECTIVE: We performed a follow-up of the German Infant Nutritional Intervention study until 6 years of life to investigate the long-term allergy-preventive effect of 3 hydrolyzed infant formulas compared with cow's milk formula (CMF) in a randomized, double-blind trial. METHODS: Between 1995 and 1998, 2252 newborns with atopic heredity were randomly assigned at birth to receive one of 4 blinded formulas: partially or extensively hydrolyzed whey formula, extensively hydrolyzed casein formula, or CMF as milk substitute for the first 4 months when breast-feeding was insufficient. The cohort was followed from birth until 6 years of age with yearly questionnaires. Outcomes were physician-diagnosed allergic diseases (atopic dermatitis, food allergy, allergic urticaria, asthma, and hay fever/allergic rhinitis). Log-binomial regression modeled with generalized estimation equations was used for the statistical analysis. RESULTS: In the intent-to-treat analysis the relative risk of a physician's diagnosis of allergic manifestation (AM) compared with CMF was 0.82 (95% CI, 0.70-0.96) for partially hydrolyzed whey formula, 0.90 (95% CI, 0.78-1.04) for extensively hydrolyzed whey formula, and 0.80 (95% CI, 0.69-0.93) for extensively hydrolyzed casein formula. The corresponding figures for atopic eczema were 0.79 (95% CI, 0.64-0.97), 0.92 (95% CI, 0.76-1.11), and 0.71 (95% CI, 0.58-0.88), respectively. In the per-protocol analysis all effects were stronger and significant. No significant effect on other AMs was found. CONCLUSION: The data confirm a long-term allergy-preventive effect of hydrolyzed infant formulas on AM and atopic eczema until 6 years of age.
Authors:
Andrea von Berg; Birgit Filipiak-Pittroff; Ursula Krämer; Elke Link; Christina Bollrath; Inken Brockow; Sibylle Koletzko; Armin Grübl; Joachim Heinrich; H-Erich Wichmann; Carl-P Bauer; Dietrich Reinhardt; Dietrich Berdel;
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  121     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-09     Completed Date:  2008-07-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1442-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, Marien-Hospital Wesel, Wesel, Germany. vonberg@marien-hospital-wesel.de.
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MeSH Terms
Descriptor/Qualifier:
Caseins
Child
Child, Preschool
Female
Follow-Up Studies
Humans
Hypersensitivity / epidemiology,  prevention & control*
Infant
Infant Formula*
Infant, Newborn
Male
Milk Proteins
Prevalence
Protein Hydrolysates
Questionnaires
Chemical
Reg. No./Substance:
0/Caseins; 0/Milk Proteins; 0/Protein Hydrolysates; 0/whey protein
Investigator
Investigator/Affiliation:
H-E Wichmann / ; J Heinrich / ; A Schoetzau / ; M Mosetter / ; J Schindler / ; A Hönke / ; K Franke / ; B Laubereau / ; S Sausenthaler / ; A Thaqi / ; A Zirngibl / ; A Zutavern / ; D Berdel / ; A von Berg / ; B Filipiak-Pittroff / ; B Albrecht / ; A Baumgart / ; Ch Bollrath / ; S Bütner / ; S Diekamp / ; I Gross / ; T Jakob / ; K Klemke / ; S Kurpiun / ; M Mölemann / ; J Neusüs Varhelyi / ; A Zorn / ; S Koletzko / ; D Reinhard / ; H Weigand / ; I Antonie / ; B Bäumler-Merl / ; C Tasch / ; R Göhlert / ; D Mühlbauer / ; C Sönnichsen / ; T Sauerwald / ; A Kindermann / ; M Waag / ; M Koch / ; C P Bauer / ; A Grübl / ; P Bartels / ; I Brockow / ; A Fischer / ; U Hoffmann / ; F Lötzbeyer / ; R Mayrl / ; K Negele / ; E-M Schill / ; B Wolf / ; U Krämer / ; E Link / ; U Ranft / ; R Schins / ; D Sugiri /

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