| Preventive effect of hydrolyzed infant formulas persists until age 6 years: long-term results from the German Infant Nutritional Intervention Study (GINI). | |
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MedLine Citation:
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PMID: 18539195 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The long-term effect of nutritional intervention with hydrolyzed infant formulas on allergy development has not been sufficiently evaluated. OBJECTIVE: We performed a follow-up of the German Infant Nutritional Intervention study until 6 years of life to investigate the long-term allergy-preventive effect of 3 hydrolyzed infant formulas compared with cow's milk formula (CMF) in a randomized, double-blind trial. METHODS: Between 1995 and 1998, 2252 newborns with atopic heredity were randomly assigned at birth to receive one of 4 blinded formulas: partially or extensively hydrolyzed whey formula, extensively hydrolyzed casein formula, or CMF as milk substitute for the first 4 months when breast-feeding was insufficient. The cohort was followed from birth until 6 years of age with yearly questionnaires. Outcomes were physician-diagnosed allergic diseases (atopic dermatitis, food allergy, allergic urticaria, asthma, and hay fever/allergic rhinitis). Log-binomial regression modeled with generalized estimation equations was used for the statistical analysis. RESULTS: In the intent-to-treat analysis the relative risk of a physician's diagnosis of allergic manifestation (AM) compared with CMF was 0.82 (95% CI, 0.70-0.96) for partially hydrolyzed whey formula, 0.90 (95% CI, 0.78-1.04) for extensively hydrolyzed whey formula, and 0.80 (95% CI, 0.69-0.93) for extensively hydrolyzed casein formula. The corresponding figures for atopic eczema were 0.79 (95% CI, 0.64-0.97), 0.92 (95% CI, 0.76-1.11), and 0.71 (95% CI, 0.58-0.88), respectively. In the per-protocol analysis all effects were stronger and significant. No significant effect on other AMs was found. CONCLUSION: The data confirm a long-term allergy-preventive effect of hydrolyzed infant formulas on AM and atopic eczema until 6 years of age. |
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Authors:
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Andrea von Berg; Birgit Filipiak-Pittroff; Ursula Krämer; Elke Link; Christina Bollrath; Inken Brockow; Sibylle Koletzko; Armin Grübl; Joachim Heinrich; H-Erich Wichmann; Carl-P Bauer; Dietrich Reinhardt; Dietrich Berdel; |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of allergy and clinical immunology Volume: 121 ISSN: 1097-6825 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-06-09 Completed Date: 2008-07-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 1442-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Marien-Hospital Wesel, Wesel, Germany. vonberg@marien-hospital-wesel.de. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Caseins Child Child, Preschool Female Follow-Up Studies Humans Hypersensitivity / epidemiology, prevention & control* Infant Infant Formula* Infant, Newborn Male Milk Proteins Prevalence Protein Hydrolysates Questionnaires |
| Chemical | |
Reg. No./Substance:
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0/Caseins; 0/Milk Proteins; 0/Protein Hydrolysates; 0/whey protein |
| Investigator | |
Investigator/Affiliation:
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H-E Wichmann / ; J Heinrich / ; A Schoetzau / ; M Mosetter / ; J Schindler / ; A Hönke / ; K Franke / ; B Laubereau / ; S Sausenthaler / ; A Thaqi / ; A Zirngibl / ; A Zutavern / ; D Berdel / ; A von Berg / ; B Filipiak-Pittroff / ; B Albrecht / ; A Baumgart / ; Ch Bollrath / ; S Bütner / ; S Diekamp / ; I Gross / ; T Jakob / ; K Klemke / ; S Kurpiun / ; M Mölemann / ; J Neusüs Varhelyi / ; A Zorn / ; S Koletzko / ; D Reinhard / ; H Weigand / ; I Antonie / ; B Bäumler-Merl / ; C Tasch / ; R Göhlert / ; D Mühlbauer / ; C Sönnichsen / ; T Sauerwald / ; A Kindermann / ; M Waag / ; M Koch / ; C P Bauer / ; A Grübl / ; P Bartels / ; I Brockow / ; A Fischer / ; U Hoffmann / ; F Lötzbeyer / ; R Mayrl / ; K Negele / ; E-M Schill / ; B Wolf / ; U Krämer / ; E Link / ; U Ranft / ; R Schins / ; D Sugiri / |
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