| Preventive effect of grape seed extract against high-fructose diet-induced insulin resistance and oxidative stress in rats. | |
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MedLine Citation:
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PMID: 20412828 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of the present study was to investigate the preventive effect of grape seed extract (GSE) on insulin resistance and oxidative stress in rats fed a high-fructose diet. After 8 weeks of the experiment, the fasting plasma glucose, insulin concentrations, and the homeostasis model assessment of basal insulin resistance (HOMA-IR) of rats fed a high-fructose diet supplemented with 1% GSE were significantly lower than that of a high-fructose diet group. In the oral glucose tolerance test, rats fed a high-fructose diet supplemented with 1% GSE had a significantly reduced plasma glucose and insulin concentrations after 15 min of glucose loading, indicating that GSE improved glucose intolerance. In addition, fed rats fed a high-fructose diet supplemented with 1% GSE markedly increased activity of hepatic superoxide dismutase, catalase, and suppressed lipid peroxidation when compared to rats fed a high-fructose diet. However, rats fed a high-fructose diet supplemented with GSE were not found to have a significant change in the activity of hepatic glutathione peroxidase. In conclusion, intake of GSE may be a feasible therapeutic strategy for prevention of a high-fructose diet-induced insulin resistance and oxidative stress. |
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Authors:
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Wannaporn Suwannaphet; Aramsri Meeprom; Sirintorn Yibchok-Anun; Sirichai Adisakwattana |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-20 |
Journal Detail:
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Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 48 ISSN: 1873-6351 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-08-04 Completed Date: 2010-11-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: England |
Other Details:
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Languages: eng Pagination: 1853-7 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Pharmacology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok 10330, Thailand. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight / drug effects Diet Drinking / drug effects Eating / drug effects Fructose / antagonists & inhibitors*, toxicity* Glucose Tolerance Test Insulin / blood Insulin Resistance / physiology Liver / drug effects, metabolism Male Oxidative Stress / drug effects* Plant Extracts / pharmacology Rats Rats, Sprague-Dawley Seeds / chemistry Vitis / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Plant Extracts; 11061-68-0/Insulin; 30237-26-4/Fructose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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