| Preventive effect of ethanol extract of Alpinia calcarata Rosc on Ehrlich's ascitic carcinoma cell induced malignant ascites in mice. | |
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MedLine Citation:
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PMID: 22221755 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To explore cytotoxic activity of ethanol extract of Alpinia calcarata Rosc (EEAC) rhizome against Ehrlich ascites carcinoma (EAC) tumor bearing Swiss Albino mice. METHODS: In the present study, its anti-neoplastic activity has been studied by monitoring parameters like tumor weight measurement, survival time, tumor cell growth inhibition, haematological characteristics etc. RESULTS: It was found that EEAC at dose 8 mg/kg/day (i.p.) significantly decreased tumor weight (62.0%; P <0.01), increased life span (70.25%; P <0.01) and reduced tumor cell growth rate (85.7%; P <0.01) in comparison to those of EAC bearing mice. The plant extract also improved the depleted haematological parameters like RBC, WBC, Hb%, differential counts (e.g. lymphocytes, neutrophils, monocytes etc) of EAC bearing mice towards normal. The host toxic effects were not very high and recovered gradually towards normal within a few days after treatment. CONCLUSIONS: EEAC exhibits potent in vivo cytotoxic activity against EAC tumor bearing Swiss Albino mice. So, the plant can be considered as a probable new source of antitumor agents. |
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Authors:
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Rasida Perveen; Farhadul Islam; Jahanara Khanum; Tanzima Yeasmin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Asian Pacific journal of tropical medicine Volume: 5 ISSN: 1995-7645 ISO Abbreviation: Asian Pac J Trop Med Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101533720 Medline TA: Asian Pac J Trop Med Country: Singapore |
Other Details:
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Languages: eng Pagination: 121-5 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Hainan Medical College. Published by Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi -6205 Bangladesh. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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