| Preventive effect of (-)epigallocatechin gallate on lipids, lipoproteins, and enzymes of lipid metabolism in isoproterenol-induced myocardial infarction in rats. | |
| | |
MedLine Citation:
|
PMID: 20024955 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This article reports data on the preventive effect of (-)epigallocatechin gallate (EGCG) on lipid metabolism and lipoproteins in isoproterenol (ISO)-induced myocardial infarction (MI) in Wistar rats. The rats were induced MI by ISO (100 mg/kg) at an interval of 24 h for 2 days. EGCG (30 mg/kg) was given to rats as pretreatment for 21 days orally using an intragastric tube. EGCG significantly reduced the increased serum levels of cholesterol, triglycerides, and free fatty acids in the heart and serum phospholipids (PLs) in ISO-treated rats. It also significantly increased the reduced levels of heart PLs in ISO-induced rats. EGCG reduced the levels of serum low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol and increased serum high-density lipoprotein (HDL)-cholesterol in ISO-treated rats. It also reduced the increased cholesterol/PL ratio and atherogenic index and significantly increased the reduced ratio of HDL-cholesterol/total cholesterol. Also EGCG significantly increased the reduced activity of lecithin cholesterol acyl transferase in ISO-treated rats. Thus, EGCG prevented the accumulation of lipids and altered the levels of lipoproteins in myocardial-infarcted rats. |
| | |
Authors:
|
P T Devika; P Stanely Mainzen Prince |
Related Documents
:
|
3391425 - Longitudinal study of plasma lipids and lipoprotein cholesterol in normal pregnancy and... 3318455 - Fenofibrate affects the compositions of lipoproteins. 20686565 - Biological, clinical and population relevance of 95 loci for blood lipids. 18218195 - Lipid abnormalities and cardiovascular risk in the elderly. 18782415 - Effects of increasing days of exposure to prepartum transition diets on milk production... 3113325 - Ascorbic acid requirement and assessment of ascorbate status in the common marmoset (ca... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of biochemical and molecular toxicology Volume: 23 ISSN: 1099-0461 ISO Abbreviation: J. Biochem. Mol. Toxicol. Publication Date: 2009 Nov-Dec |
Date Detail:
|
Created Date: 2009-12-24 Completed Date: 2010-03-10 Revised Date: 2011-03-18 |
Medline Journal Info:
|
Nlm Unique ID: 9717231 Medline TA: J Biochem Mol Toxicol Country: United States |
Other Details:
|
Languages: eng Pagination: 387-93 Citation Subset: IM |
Affiliation:
|
Department of Biochemistry and Biotechnology, Annamalai University, Annamalainagar 608002, Tamil Nadu, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Catechin / analogs & derivatives*, pharmacology Cholesterol, LDL / blood Cholesterol, VLDL / blood Isoproterenol / pharmacology* Lipid Metabolism / drug effects* Lipoproteins / metabolism* Male Myocardial Infarction / metabolism* Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
|
0/Cholesterol, LDL; 0/Cholesterol, VLDL; 0/Lipoproteins; 154-23-4/Catechin; 7683-59-2/Isoproterenol; 989-51-5/epigallocatechin gallate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effects of osmotic stress on the structure and function of the cell nucleus.
Next Document: Metabolism of the mesoionic compound (MI-D) by mouse liver microsome, detection of its metabolite in...