| Preventive effect of dapsone on renal scarring following mannose-sensitive piliated bacterial infection. | |
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MedLine Citation:
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PMID: 9444407 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Renal scarring has been thought to occur in the later stages of chronic pyelonephritis. We previously reported that mannose-sensitive (MS) piliated bacteria promoted renal scarring, which was prevented by antioxidants. The preventive effect of diaphenylsulfone (dapsone), which has a scavenging activity on active oxygen species, on renal scarring was examined. Female Sprague-Dawley rats were inoculated with clinical isolates of Serratia marcescens which had both MS and mannose-resistant pili or with recombinant strains which had MS pili on their surface; they were then administered 20 mg/kg of dapsone or not. Dapsone significantly suppressed scarring following infection of the kidney. The bacterial counts in the kidneys were not different in dapsone-treated and nontreated rats. We conclude that dapsone is effective in preventing renal scarring, and it is suggested that the clinical use of this drug may prevent renal scar formation following pyelonephritis. |
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Authors:
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O Mochida; T Matsumoto; Y Mizunoe; M Sakumoto; J Abe; J Kumazawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chemotherapy Volume: 44 ISSN: 0009-3157 ISO Abbreviation: Chemotherapy Publication Date: 1998 Jan-Feb |
Date Detail:
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Created Date: 1998-02-27 Completed Date: 1998-02-27 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0144731 Medline TA: Chemotherapy Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 36-41 Citation Subset: IM |
Affiliation:
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Department of Urology, Faculty of Medicine, Kyushu University, Fukuoka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Bacterial Agents / therapeutic use* Dapsone / therapeutic use* Female Fimbriae, Bacterial / drug effects Kidney / microbiology Kidney Diseases / microbiology, prevention & control* Mannose / pharmacology* Rats Rats, Sprague-Dawley Sensitivity and Specificity Serratia Infections / complications*, drug therapy* Serratia marcescens* |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 31103-86-3/Mannose; 80-08-0/Dapsone |
| Comments/Corrections | |
Comment In:
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Chemotherapy. 1999 May-Jun;45(3):233-5
[PMID:
10408927
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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