| Preventive effect of chlorogenic Acid on lens opacity and cytotoxicity in human lens epithelial cells. | |
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MedLine Citation:
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PMID: 21628897 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The present study reveals the pharmacological effect of chlorogenic acid, a major phenolic compound in plants, food, and coffee, on diabetic cataracts. Chlorogenic acid examined the inhibitory effects upon rat lens aldose reductase (AR) activity and xylose-induced rat lens opacity. The effect of chlorogenic acid on high glucose-induced cytotoxicity in lens epithelial cells was also examined. Chlorogenic acid showed potential inhibitory activity against rat lens AR, with an IC(50) value of 0.95 µM. The xylose-induced opacity of lenses was significantly improved after treatment with chlorogenic acid in a dose-dependent manner. Chlorogenic acid prevented high glucose-induced cytotoxicity in human lens epithelial (HLE-B3) cells in a dose-dependent manner. These results suggest that chlorogenic acid may provide a potential therapeutic approach for prevention of diabetic complications, such as cataracts. |
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Authors:
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Young Sook Kim; Nan Hee Kim; Yun Mi Lee; Jin Sook Kim |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biological & pharmaceutical bulletin Volume: 34 ISSN: 1347-5215 ISO Abbreviation: Biol. Pharm. Bull. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-06-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9311984 Medline TA: Biol Pharm Bull Country: Japan |
Other Details:
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Languages: eng Pagination: 925-8 Citation Subset: IM |
Affiliation:
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Diabetic Complications Research Center, Division of Traditional Korean Medicine (TKM) Integrated Research, Korea Institute of Oriental Medicine (KIOM). |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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