| Preventive effect of botulinum toxin A in microanastomotic thrombosis: a rabbit model. | |
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MedLine Citation:
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PMID: 20673655 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Microvascular free tissue transfers play an important role in the reconstruction of body defects. Various aetiologies lead to vascular thrombosis and free-flap failure. In this study, the effects of botulinum toxin A on vessel diameters and prevention of anastomotic thrombosis were studied in a blinded vasospasm model in rabbits. METHODS: One side of 16 adult rabbit ears was pre-treated with botulinum toxin type A, and normal saline injections were performed as control in the contralateral side. Seven days later, vessel diameters were measured in both the groups; the vessels were then cut and reanastomosed after vasospastic challenge and vessel patencies were evaluated. RESULTS: Both artery and vein diameters were significantly larger in the botulinum toxin A group (P=0.002 and < 0.001, respectively). The patency rate of arterial and venous anastomosis was significantly higher in the neurotoxin pre-treated group (P=0.038 and 0.003, respectively). CONCLUSION: This study shows that pre-treatment with botulinum toxin type A is associated with a lower rate of arterial and venous thrombosis in rabbit-model microanastomosis. Further studies are necessary to evaluate its ability to decrease vasospasm and thrombosis in free-flap survival of humans. |
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Authors:
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Mehdi Fathi; Hamidreza Fathi; Mehdi Mazloumi; Omid Khalilzadeh; Saeid Amanpour; Alipasha Meysamie; Leila Mashali; Mohammad H Kardar |
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Publication Detail:
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Type: Journal Article Date: 2010-07-29 |
Journal Detail:
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Title: Journal of plastic, reconstructive & aesthetic surgery : JPRAS Volume: 63 ISSN: 1878-0539 ISO Abbreviation: J Plast Reconstr Aesthet Surg Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-13 Completed Date: 2010-10-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101264239 Medline TA: J Plast Reconstr Aesthet Surg Country: Netherlands |
Other Details:
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Languages: eng Pagination: e720-4 Citation Subset: IM |
Copyright Information:
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Copyright 2010 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Division of Plastic and Reconstructive Surgery, Imam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anastomosis, Surgical Animals Botulinum Toxin Type A / pharmacology* Disease Models, Animal Postoperative Complications / prevention & control* Rabbits Random Allocation Surgical Flaps / blood supply Thrombosis / etiology, prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Botulinum Toxin Type A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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