Document Detail


Preventive effect of botulinum toxin A in microanastomotic thrombosis: a rabbit model.
MedLine Citation:
PMID:  20673655     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Microvascular free tissue transfers play an important role in the reconstruction of body defects. Various aetiologies lead to vascular thrombosis and free-flap failure. In this study, the effects of botulinum toxin A on vessel diameters and prevention of anastomotic thrombosis were studied in a blinded vasospasm model in rabbits. METHODS: One side of 16 adult rabbit ears was pre-treated with botulinum toxin type A, and normal saline injections were performed as control in the contralateral side. Seven days later, vessel diameters were measured in both the groups; the vessels were then cut and reanastomosed after vasospastic challenge and vessel patencies were evaluated. RESULTS: Both artery and vein diameters were significantly larger in the botulinum toxin A group (P=0.002 and < 0.001, respectively). The patency rate of arterial and venous anastomosis was significantly higher in the neurotoxin pre-treated group (P=0.038 and 0.003, respectively). CONCLUSION: This study shows that pre-treatment with botulinum toxin type A is associated with a lower rate of arterial and venous thrombosis in rabbit-model microanastomosis. Further studies are necessary to evaluate its ability to decrease vasospasm and thrombosis in free-flap survival of humans.
Authors:
Mehdi Fathi; Hamidreza Fathi; Mehdi Mazloumi; Omid Khalilzadeh; Saeid Amanpour; Alipasha Meysamie; Leila Mashali; Mohammad H Kardar
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Publication Detail:
Type:  Journal Article     Date:  2010-07-29
Journal Detail:
Title:  Journal of plastic, reconstructive & aesthetic surgery : JPRAS     Volume:  63     ISSN:  1878-0539     ISO Abbreviation:  J Plast Reconstr Aesthet Surg     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-13     Completed Date:  2010-10-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264239     Medline TA:  J Plast Reconstr Aesthet Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  e720-4     Citation Subset:  IM    
Copyright Information:
Copyright 2010 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Division of Plastic and Reconstructive Surgery, Imam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
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MeSH Terms
Descriptor/Qualifier:
Anastomosis, Surgical
Animals
Botulinum Toxin Type A / pharmacology*
Disease Models, Animal
Postoperative Complications / prevention & control*
Rabbits
Random Allocation
Surgical Flaps / blood supply
Thrombosis / etiology,  prevention & control*
Chemical
Reg. No./Substance:
0/Botulinum Toxin Type A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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