Document Detail

Preventive effect of botulinum toxin A in microanastomotic thrombosis: a rabbit model.
MedLine Citation:
PMID:  20673655     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Microvascular free tissue transfers play an important role in the reconstruction of body defects. Various aetiologies lead to vascular thrombosis and free-flap failure. In this study, the effects of botulinum toxin A on vessel diameters and prevention of anastomotic thrombosis were studied in a blinded vasospasm model in rabbits. METHODS: One side of 16 adult rabbit ears was pre-treated with botulinum toxin type A, and normal saline injections were performed as control in the contralateral side. Seven days later, vessel diameters were measured in both the groups; the vessels were then cut and reanastomosed after vasospastic challenge and vessel patencies were evaluated. RESULTS: Both artery and vein diameters were significantly larger in the botulinum toxin A group (P=0.002 and < 0.001, respectively). The patency rate of arterial and venous anastomosis was significantly higher in the neurotoxin pre-treated group (P=0.038 and 0.003, respectively). CONCLUSION: This study shows that pre-treatment with botulinum toxin type A is associated with a lower rate of arterial and venous thrombosis in rabbit-model microanastomosis. Further studies are necessary to evaluate its ability to decrease vasospasm and thrombosis in free-flap survival of humans.
Mehdi Fathi; Hamidreza Fathi; Mehdi Mazloumi; Omid Khalilzadeh; Saeid Amanpour; Alipasha Meysamie; Leila Mashali; Mohammad H Kardar
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Publication Detail:
Type:  Journal Article     Date:  2010-07-29
Journal Detail:
Title:  Journal of plastic, reconstructive & aesthetic surgery : JPRAS     Volume:  63     ISSN:  1878-0539     ISO Abbreviation:  J Plast Reconstr Aesthet Surg     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-13     Completed Date:  2010-10-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264239     Medline TA:  J Plast Reconstr Aesthet Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  e720-4     Citation Subset:  IM    
Copyright Information:
Copyright 2010 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.
Division of Plastic and Reconstructive Surgery, Imam Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.
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MeSH Terms
Anastomosis, Surgical
Botulinum Toxin Type A / pharmacology*
Disease Models, Animal
Postoperative Complications / prevention & control*
Random Allocation
Surgical Flaps / blood supply
Thrombosis / etiology,  prevention & control*
Reg. No./Substance:
0/Botulinum Toxin Type A

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