| Preventive antibiotic usage in traumatic thoracic injuries requiring closed tube thoracostomy. | |
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MedLine Citation:
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PMID: 7956409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the safety and effectiveness of antibiotics in reducing the infectious complications following closed tube thoracostomy for isolated chest trauma. DESIGN: Double-blind, randomized clinical trial. SETTING: Medical school affiliated large urban teaching hospital and trauma center. PATIENTS: One hundred nineteen of 159 patients over 18 years old presenting to the emergency department requiring closed tube thoracostomy for isolated chest injuries (113 penetrating, 6 blunt). INTERVENTION: Patients received either placebo or 1 g cefonicid daily intravenously started at chest tube insertion and stopped within 24 h of removal. MEASUREMENTS AND RESULTS: The development of wound infections, pneumonia (CDC criteria), or empyema; the incidence of adverse events; length of hospitalization. One nonspecific infection was seen in the cefonicid group (1.6 percent) and six respiratory tract infections (10.7 percent) in the placebo group (three empyema, one empyema with pneumonia, two pneumonia) (p = 0.0505; p = 0.0094 [excluding nonspecific infection]). No significant differences with antibiotic use were seen in the duration of chest tube use (p = 0.766), peak WBC counts (p = 0.108), lower peak temperatures (p = 0.063), or length of hospitalization (p = 0.165). Patients who developed infectious complications averaged approximately 8 days longer hospitalization than those without (p < 0.0001). CONCLUSION: This study showed that patients receiving antibiotics had a significantly reduced rate of infection than did patients administered placebo. No significant adverse events were seen in either group. |
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Authors:
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R L Nichols; J W Smith; A C Muzik; E J Love; N E McSwain; G Timberlake; L M Flint |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Chest Volume: 106 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 1994 Nov |
Date Detail:
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Created Date: 1994-12-09 Completed Date: 1994-12-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1493-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, Tulane University School of Medicine, New Orleans, LA 70112-2699. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Cefonicid / adverse effects, therapeutic use* Chest Tubes* Chi-Square Distribution Delayed-Action Preparations Double-Blind Method Female Humans Male Middle Aged Premedication* / statistics & numerical data Prospective Studies Statistics, Nonparametric Surgical Wound Infection / prevention & control Thoracic Injuries / complications, surgery* Thoracostomy* Wounds, Nonpenetrating / complications, surgery* Wounds, Penetrating / complications, surgery* |
| Chemical | |
Reg. No./Substance:
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0/Delayed-Action Preparations; 61270-58-4/Cefonicid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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