Document Detail

Prevention of ventricular fibrillation with magnesium sulfate.
MedLine Citation:
PMID:  3220116     Owner:  NLM     Status:  MEDLINE    
Mongrel dogs with healed myocardial infarctions were given a 2 min coronary occlusion during an exercise test. The exercise plus ischemia test induced ventricular fibrillation in nine animals. One week later, the test was repeated after pretreatment with magnesium sulfate (100 mg/kg i.v.). Magnesium prevented ventricular fibrillation in seven of the nine animals without adverse side effects. Thus, magnesium may be useful in the management of ventricular fibrillation during ischemia.
G E Billman; R S Hoskins
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European journal of pharmacology     Volume:  158     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1988 Dec 
Date Detail:
Created Date:  1989-03-17     Completed Date:  1989-03-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  167-71     Citation Subset:  IM    
Department of Physiology, Ohio State University, Columbus 43210-1239.
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MeSH Terms
Coronary Disease / complications,  physiopathology
Hemodynamics / drug effects
Magnesium Sulfate / pharmacology*
Myocardial Infarction / complications,  physiopathology
Physical Exertion
Ventricular Fibrillation / etiology,  prevention & control*
Grant Support
Reg. No./Substance:
7487-88-9/Magnesium Sulfate

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