Document Detail


Prevention of ventricular fibrillation requires central beta-adrenoceptor blockade in rabbits.
MedLine Citation:
PMID:  17680509     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To study whether and how a lipophilic and a hydrophilic beta-adrenoceptor antagonist affects ventricular fibrillation (VF) after coronary artery occlusion in a rabbit model with high sympathetic and low cardiac vagal activation. DESIGN: Rabbits were treated for 3 weeks (series 1) or 2 hours (series 2) with metoprolol, atenolol or control vehicle. Finally the animals in series 1 were exposed to coronary artery occlusion. Heart rate response to cholinergic blockade was studied in series 2. RESULTS: The incidence of postocclusion VF in metoprolol animals was lower (p<0.05) than that in atenolol or control animals. The two beta-blockers caused similar reductions of heart rate, arterial pressure and myocardial ischemia. However, metoprolol animals had more respiratory sinus arrhythmia higher baroreflex sensitivity and more pronounced tachycardic response to cholinergic blockade than atenolol animals. CONCLUSION: Metoprolol reduced the incidence of VF by a better maintained discharge than atenolol in efferent cardiac vagal nerves, possibly due to inhibition of central nervous beta(1) adrenoceptors modulating vagal nervous outflow.
Authors:
Bengt Ablad; Thorvald Bjurö; Jan-Arne Björkman; Therese Edström
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Scandinavian cardiovascular journal : SCJ     Volume:  41     ISSN:  1401-7431     ISO Abbreviation:  Scand. Cardiovasc. J.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-07     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708377     Medline TA:  Scand Cardiovasc J     Country:  England    
Other Details:
Languages:  eng     Pagination:  221-9     Citation Subset:  IM    
Affiliation:
AstraZeneca R&D, Mölndal, Sweden. bengt.ablad@astrazeneca.com
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / pharmacology*
Animals
Atenolol / pharmacology
Baroreflex / drug effects
Blood Pressure / drug effects
Central Nervous System / drug effects
Disease Models, Animal
Heart Rate / drug effects
Male
Metoprolol / pharmacology
Myocardial Ischemia / complications
Rabbits
Receptors, Adrenergic, beta-1 / drug effects*
Ventricular Fibrillation / drug therapy,  etiology,  prevention & control*
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Receptors, Adrenergic, beta-1; 29122-68-7/Atenolol; 37350-58-6/Metoprolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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