| Prevention of type 1 diabetes. | |
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MedLine Citation:
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PMID: 21981959 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Prevention of loss of b cells in type 1 diabetes is a major goal of current research. Knowledge of the genetic susceptibility, increasing ability to predict who may be at risk, recognition of the potential clinical impact of residual insulin secretion after diagnosis, and development of new immunomodulatory agents have supported an increasing number of clinical trials to prevent b-cell loss. Interventions can be targeted at 3 stages: before the development of autoimmunity (primary prevention), after autoimmunity is recognized (secondary prevention), or after diagnosis when significant numbers of b cells remain (tertiary prevention). Thus far, several agents show promise when given shortly after diagnosis, but no interventions before diagnosis have shown benefit. Knowledge in this area has grown quickly in recent years and will continue to grow rapidly with several international collaborative efforts underway. |
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Authors:
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Diane K Wherrett; Denis Daneman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric clinics of North America Volume: 58 ISSN: 1557-8240 ISO Abbreviation: Pediatr. Clin. North Am. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401126 Medline TA: Pediatr Clin North Am Country: United States |
Other Details:
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Languages: eng Pagination: 1257-70 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Endocrinology, Department of Pediatrics, The Hospital for Sick Children and University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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