| Prevention and treatment of postpartum endometritis. | |
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MedLine Citation:
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PMID: 12844449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Postpartum endometritis is an important cause of maternal morbidity after cesarean section. Prophylactic antibiotic therapy reduces the risk by approximately 60%. The benefit of antibiotic therapy for laboring women has been established. For nonlaboring patients, there is still some uncertainty. Intravaginal metronidazole as surgical preparation and oral methylergometrine after delivery are two interventions that show promise as additional prophylactic interventions. The gold standard therapy, once endometritis has been diagnosed, is intravenous clindamycin and gentamicin. If an alternative regimen is chosen, it should have a similar spectrum, including good coverage for gram-positive anaerobes such as Bacteroides fragilis. Antibiotic therapy can be discontinued once the patient is afebrile without continued oral antibiotics. Treatment failure occurs in approximately 10% of cases and should trigger investigation of other infectious complications. Prolonged fever of undetermined etiology is not uncommon and requires prolonged antibiotic therapy, with or without heparin. |
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Authors:
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Linda French |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current women's health reports Volume: 3 ISSN: 1534-5874 ISO Abbreviation: Curr Womens Health Rep Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-07-07 Completed Date: 2003-09-24 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 101120027 Medline TA: Curr Womens Health Rep Country: United States |
Other Details:
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Languages: eng Pagination: 274-9 Citation Subset: IM |
Affiliation:
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Department of Family Practice, College of Human Medicine, Michigan State University, B101 Clinical Center, East Lansing, MI 48824, USA. Linda.French@ht.msu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Infective Agents
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therapeutic use Cesarean Section / adverse effects Endometritis / complications, drug therapy, prevention & control* Female Fever / etiology Humans Puerperal Infection / complications, drug therapy, prevention & control* Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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