Document Detail

Prevention and treatment of invasive fungal infection in very low birthweight infants.
MedLine Citation:
PMID:  18838467     Owner:  NLM     Status:  MEDLINE    
Invasive fungal infection is an important cause of mortality and morbidity in very low birthweight (VLBW) infants. Extremely preterm and extremely low birthweight infants are at highest risk because of the intensive and invasive nature of the care that these infants receive. Additional specific risk factors include prolonged use of parenteral nutrition and exposure to broad-spectrum antibiotics and histamine type 2 receptor blockers. Diagnosis is difficult and often delayed, and this may contribute to the high levels of deep-organ dissemination and associated mortality and morbidity. The most commonly used antifungal agents are amphotericin B and fluconazole. Recent research has assessed the value of early empirical and prophylactic treatment. However, although systemic antifungal prophylaxis reduces the incidence of invasive fungal infection, there is no evidence of effect on mortality. Concern exists about the impact that widespread use of prophylaxis may have on the emergence of antifungal resistance.
M Brecht; L Clerihew; W McGuire
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-10-06
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  94     ISSN:  1468-2052     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-23     Completed Date:  2009-02-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  England    
Other Details:
Languages:  eng     Pagination:  F65-9     Citation Subset:  AIM; IM    
Australian National University Medical School, Canberra, Australia.
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MeSH Terms
Amphotericin B / therapeutic use*
Antifungal Agents / therapeutic use*
Candidiasis / drug therapy,  mortality,  prevention & control*
Catheterization, Central Venous / adverse effects*
Device Removal / adverse effects
Fluconazole / therapeutic use*
Infant, Newborn
Infant, Premature / immunology
Infant, Very Low Birth Weight / immunology
Intensive Care, Neonatal / standards
Microbial Sensitivity Tests
Reg. No./Substance:
0/Antifungal Agents; 1397-89-3/Amphotericin B; 86386-73-4/Fluconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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