Document Detail


Prevention of toxoplasmosis in transplant patients.
MedLine Citation:
PMID:  19018809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Toxoplasmosis is a life-threatening opportunistic infection that affects haematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT) recipients. Its incidence in these patients is closely related to the prevalence of toxoplasmosis in the general population, which is high in Europe. In SOT recipients, toxoplasmosis results mainly from transmission of the parasite with the transplanted organ from a Toxoplasma-seropositive donor to a Toxoplasma-seronegative recipient. This risk is high in cases of transplantation of organs that are recognized sites of encystation of the parasite, e.g. the heart, and is markedly lower in other SOT recipients. Clinical symptoms usually occur within the first 3 months after transplantation, sometimes as early as 2 weeks post transplant, and involve febrile myocarditis, encephalitis or pneumonitis. In HSCT recipients, the major risk of toxoplasmosis results from the reactivation of a pre-transplant latent infection in seropositive recipients. The median point of disease onset is estimated at 2 months post transplant, with <10% of cases occurring before 30 days and 15-20% later than day 100. Toxoplasmosis usually manifests as encephalitis or pneumonitis, and frequently disseminates with multiple organ involvement. Diagnosis of toxoplasmosis is based on the demonstration of parasites or parasitic DNA in blood, bone marrow, cerebrospinal fluid, bronchoalveolar lavage fluid or biopsy specimens, and serological tests do not often contribute to the diagnosis. For prevention of toxoplasmosis, serological screening of donors and recipients before transplantation allows the identification of patients at higher risk of toxoplasmosis, i.e. seropositive HSCT recipients and mismatched (seropositive donor/seronegative recipients) SOT recipients. Preventing toxoplasmosis disease in those patients presently relies on prophylaxis via prescription of co-trimoxazole.
Authors:
F Derouin; H Pelloux;
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases     Volume:  14     ISSN:  1469-0691     ISO Abbreviation:  Clin. Microbiol. Infect.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-16     Completed Date:  2009-01-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9516420     Medline TA:  Clin Microbiol Infect     Country:  France    
Other Details:
Languages:  eng     Pagination:  1089-101     Citation Subset:  IM    
Affiliation:
Laboratory of Parasitology and Mycology, University Paris and Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, Paris, France. francis.derouin@sls.aphp.fr
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MeSH Terms
Descriptor/Qualifier:
Disease Transmission, Infectious / prevention & control*
Humans
Toxoplasmosis / epidemiology,  physiopathology,  prevention & control*,  transmission
Transplantation*
Investigator
Investigator/Affiliation:
B Evengård / ; E Petersen / ; F Peyron / ; A Mathis / ; T van Gool / ; P Chiodini / ; M Junie / ; L Kortbeek /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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