Document Detail

Prevention of tourniquet pain by spinal isobaric bupivacaine with clonidine.
MedLine Citation:
PMID:  2765348     Owner:  NLM     Status:  MEDLINE    
In order to assess the effect of spinal clonidine on tourniquet pain, 30 patients scheduled to undergo orthopaedic surgery under spinal anaesthesia were allocated randomly to two groups. Patients in group I (n = 15) received 0.5% isobaric bupivacaine 15 mg plus isotonic saline 1 ml. Patients in group II (n = 15) received 0.5% bupivacaine 15 mg plus clonidine 1 ml (150 micrograms). Sensory block was evaluated by pinprick and motor block with Bromage's scale. The presence of clonidine significantly prolonged the duration of sensory and motor block. Three patients in group I, but none in group II, experienced tourniquet pain. Hypotension and bradycardia were not worsened by spinal clonidine. The use of clonidine may be a useful technique to augment bupivacaine spinal block.
F Bonnet; A Diallo; M Saada; M Belon; M Guilbaud; O Boico
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  63     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-09-28     Completed Date:  1989-09-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  93-6     Citation Subset:  IM    
Département d'Anesthésie Réanimation No. II, Hôpital Henri Mondor, Creteil, France.
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MeSH Terms
Anesthesia, Spinal*
Bupivacaine* / administration & dosage
Clonidine* / administration & dosage
Drug Evaluation
Pain / prevention & control*
Prospective Studies
Random Allocation
Sensation / drug effects
Specific Gravity
Time Factors
Tourniquets / adverse effects*
Reg. No./Substance:
2180-92-9/Bupivacaine; 4205-90-7/Clonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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