| Prevention and therapy of postresuscitation neurologic dysfunction. | |
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MedLine Citation:
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PMID: 18467891 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: The majority of cardiac arrest patients die after successful resuscitation. Despite disappointing survival rates, cardiac arrest research mainly focuses on new therapies applied during cardiac arrest in the out-of-hospital setting, but only little attention is given to therapies mitigating the so-called postresuscitation syndrome. Optimized postresuscitation hospital care might have the potential to substantially improve survival rate in patients after cardiac arrest. RECENT FINDINGS: The article will review some aspects of optimized postresuscitation care with the main emphasis on temperature control. Various aspects of ventilation strategies, metabolic control, haemodynamic stabilization, and reperfusion therapies will be summarized. SUMMARY: Therapeutic mild hypothermia (32-34 degrees C) is currently the most advanced medical concept to prevent or mitigate the postresuscitation syndrome. Large prospective randomized clinical trials are needed to investigate normoventilation with blood gases within physiologic range, moderately elevated blood glucose levels, a mean arterial pressure above 80 mmHg, and early reperfusion therapy in all cardiac arrest patients. |
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Authors:
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Wilhelm Behringer |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current opinion in critical care Volume: 14 ISSN: 1531-7072 ISO Abbreviation: Curr Opin Crit Care Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-09 Completed Date: 2008-07-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9504454 Medline TA: Curr Opin Crit Care Country: United States |
Other Details:
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Languages: eng Pagination: 305-10 Citation Subset: IM |
Affiliation:
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Department of Emergency Medicine, Vienna General Hospital, Vienna, Austria. wilhelm.behringer@meduniwien.ac.at |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Regulation Humans Hypothermia, Induced Nervous System Diseases / etiology, prevention & control*, therapy* Resuscitation / adverse effects* Survival Rate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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