Document Detail

Prevention of sudden cardiac death with omega-3 fatty acids in patients with coronary heart disease: a meta-analysis of randomized controlled trials.
MedLine Citation:
PMID:  19148838     Owner:  NLM     Status:  MEDLINE    
AIM: To systematically review trials concerning the effects of omega-3 fatty acids on sudden cardiac death (SCD), cardiac death, and all-cause mortality in coronary heart disease (CHD) patients. METHODS: PubMed, Embase, and the Cochrane database (1966-2007) were searched. We identified randomized controlled trials that compared dietary or supplementary intake of omega-3 fatty acids with control diet or placebo in CHD patients. Eligible studies had at least 6 months of follow-up data, and cited SCD as an end-point. Two reviewers independently assessed methodological quality. Meta-analysis of relative risk was carried out using the random effect model. RESULTS: Eight trials were identified, comprising 20,997 patients. In patients with prior myocardial infarction (MI), omega-3 fatty acids reduced relative risk (RR) of SCD (RR = 0.43; 95% CI: 0.20-0.91). In patients with angina, omega-3 fatty acids increased RR of SCD (RR = 1.39; 95% CI: 1.01-1.92). Overall, RR for cardiac death and all-cause mortality were 0.71 (95% CI: 0.50-1.00) and 0.77 (95% CI: 0.58-1.01), respectively. CONCLUSIONS: Dietary supplementation with omega-3 fatty acids reduces the incidence of sudden cardiac death in patients with MI, but may have adverse effects in angina patients.
Yun-Tao Zhao; Qiang Chen; Ya-Xun Sun; Xue-Bin Li; Ping Zhang; Yuan Xu; Ji-Hong Guo
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of medicine     Volume:  41     ISSN:  1365-2060     ISO Abbreviation:  Ann. Med.     Publication Date:  2009  
Date Detail:
Created Date:  2009-04-13     Completed Date:  2009-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8906388     Medline TA:  Ann Med     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  301-10     Citation Subset:  IM    
Department of Cardiology, Peking University People's Hospital, No. 11 Xizhimen South Street, Beijing, China.
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MeSH Terms
Angina Pectoris / diet therapy
Coronary Disease / complications,  mortality
Death, Sudden, Cardiac / etiology,  prevention & control*
Dietary Supplements
Fatty Acids, Omega-3 / therapeutic use*
Myocardial Infarction / diet therapy
Randomized Controlled Trials as Topic
Reg. No./Substance:
0/Fatty Acids, Omega-3

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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