| Prevention of sudden cardiac death with omega-3 fatty acids in patients with coronary heart disease: a meta-analysis of randomized controlled trials. | |
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MedLine Citation:
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PMID: 19148838 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To systematically review trials concerning the effects of omega-3 fatty acids on sudden cardiac death (SCD), cardiac death, and all-cause mortality in coronary heart disease (CHD) patients. METHODS: PubMed, Embase, and the Cochrane database (1966-2007) were searched. We identified randomized controlled trials that compared dietary or supplementary intake of omega-3 fatty acids with control diet or placebo in CHD patients. Eligible studies had at least 6 months of follow-up data, and cited SCD as an end-point. Two reviewers independently assessed methodological quality. Meta-analysis of relative risk was carried out using the random effect model. RESULTS: Eight trials were identified, comprising 20,997 patients. In patients with prior myocardial infarction (MI), omega-3 fatty acids reduced relative risk (RR) of SCD (RR = 0.43; 95% CI: 0.20-0.91). In patients with angina, omega-3 fatty acids increased RR of SCD (RR = 1.39; 95% CI: 1.01-1.92). Overall, RR for cardiac death and all-cause mortality were 0.71 (95% CI: 0.50-1.00) and 0.77 (95% CI: 0.58-1.01), respectively. CONCLUSIONS: Dietary supplementation with omega-3 fatty acids reduces the incidence of sudden cardiac death in patients with MI, but may have adverse effects in angina patients. |
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Authors:
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Yun-Tao Zhao; Qiang Chen; Ya-Xun Sun; Xue-Bin Li; Ping Zhang; Yuan Xu; Ji-Hong Guo |
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Publication Detail:
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Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of medicine Volume: 41 ISSN: 1365-2060 ISO Abbreviation: Ann. Med. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-04-13 Completed Date: 2009-07-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8906388 Medline TA: Ann Med Country: Sweden |
Other Details:
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Languages: eng Pagination: 301-10 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Peking University People's Hospital, No. 11 Xizhimen South Street, Beijing, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angina Pectoris
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diet therapy Coronary Disease / complications, mortality Death, Sudden, Cardiac / etiology, prevention & control* Dietary Supplements Fatty Acids, Omega-3 / therapeutic use* Humans Myocardial Infarction / diet therapy Randomized Controlled Trials as Topic |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Omega-3 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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