Document Detail


Prevention of strychnine-induced seizures and death by the N-methylated glycine derivatives betaine, dimethylglycine and sarcosine.
MedLine Citation:
PMID:  2581277     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Betaine (N,N,N-trimethylglycine) and N,N-dimethylglycine have been reported to have anticonvulsant properties in animals. The purpose of the present study was to determine whether these compounds can antagonize strychnine-induced seizures when administered intraperitoneally and to compare their effects with those of sarcosine (N-methylglycine) and glycine. Betaine, N,N-dimethylglycine and sarcosine were equipotent in decreasing the incidence of seizures and death, causing a 38 to 72 percent decrease in the incidence of seizures and death at a dosage of 5 mmole/kg. Glycine had no effect. Thus anticonvulsant activity is conferred to glycine by a single N-methylation.
Authors:
W J Freed
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  22     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-06-20     Completed Date:  1985-06-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  641-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Anticonvulsants*
Betaine / pharmacology*
Female
Glycine / analogs & derivatives*
Mice
Sarcosine / analogs & derivatives*,  pharmacology*
Seizures / chemically induced,  prevention & control*
Strychnine / antagonists & inhibitors*,  toxicity
Chemical
Reg. No./Substance:
0/Anticonvulsants; 107-43-7/Betaine; 107-97-1/Sarcosine; 1118-68-9/dimethylglycine; 56-40-6/Glycine; 57-24-9/Strychnine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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