Document Detail


Prevention of spontaneous bleeding in dogs with haemophilia A and haemophilia B.
MedLine Citation:
PMID:  20586797     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dogs with haemophilia A or haemophilia B exhibit spontaneous bleeding comparable with the spontaneous bleeding phenotype that occurs in humans with severe haemophilia. The phenotypic and genotypic characteristics of haemophilic dogs have been well-described, and such dogs are suitable for testing prophylactic protein replacement therapy and gene transfer strategies. In dogs with haemophilia, long-term effects on spontaneous bleeding frequency (measured over years) can be used as an efficacy endpoint in such studies. Although complete correction of coagulopathy has not been achieved, published data show that prophylactic factor replacement therapy and gene transfer can markedly reduce the frequency of spontaneous bleeding in haemophilic dogs. Further studies are currently ongoing.
Authors:
T C Nichols; R A Raymer; H W G Franck; E P Merricks; D A Bellinger; N DeFriess; P Margaritis; V R Arruda; M A Kay; K A High
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Haemophilia : the official journal of the World Federation of Hemophilia     Volume:  16 Suppl 3     ISSN:  1365-2516     ISO Abbreviation:  Haemophilia     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-30     Completed Date:  2011-01-05     Revised Date:  2014-01-08    
Medline Journal Info:
Nlm Unique ID:  9442916     Medline TA:  Haemophilia     Country:  England    
Other Details:
Languages:  eng     Pagination:  19-23     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Dogs
Factor IX / therapeutic use*
Genetic Therapy* / methods
Hemophilia A / therapy*
Hemophilia B / therapy*
Hemorrhage / prevention & control*
Grant Support
ID/Acronym/Agency:
HL063098/HL/NHLBI NIH HHS; HL64274/HL/NHLBI NIH HHS; P01 HL064190/HL/NHLBI NIH HHS; P01 HL074124/HL/NHLBI NIH HHS; R24 HL063098-11/HL/NHLBI NIH HHS; R24 HL063098-13/HL/NHLBI NIH HHS; //Howard Hughes Medical Institute
Chemical
Reg. No./Substance:
9001-28-9/Factor IX
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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