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Prevention of severe acute pancreatitis with octreotide in obese patients: a prospective multi-center randomized controlled trial.
MedLine Citation:
PMID:  23086244     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVES: To evaluate the efficacy of octreotide in preventing severe acute pancreatitis (SAP) in obese patients.
METHODS: A prospective multi-center partly randomized control trial was conducted in patients with mild acute pancreatitis (AP). Nonobese patients received conventional management (nonobese-C, n = 82), whereas obese patients (body mass index ≥25 kg/m) were randomized into 2 groups: obese-C (n = 79), who received conventional management, and obese-C+O (n = 82), who received conventional management plus intravenous infusion of octreotide, 50 μg/h for 72 hours.
RESULTS: The risk ratio and relative risk reduction in the development of SAP in the obese-C+O group were 0.27 (95% confidence interval, 0.10-0.69) and 0.73 (95% confidence interval, 0.31-0.90), respectively. The number of cases developing local complications in the obese-C+O group was significantly smaller than that in the obese-C group: 4.9% vs 19%, P = 0.006. The plasma level of somatostatin in the obese-C+O group was significantly higher than that in the obese-C group: 165.5 ± 42.6 vs 112.1 ± 24.86 pg/mL, P < 0.05. Supplement of octreotide also accompanied with reduction in plasma levels of tumor necrosis factor α and IL-6.
CONCLUSIONS: Intravenous administration of octreotide (50 μg/h) for 72 hours in the early stage of AP could prevent the development of SAP effectively in obese patients by raising plasma somatostatin to a normal level and reducing circulating cytokines.
Authors:
Fan Yang; Hao Wu; Yanqing Li; Zhaoshen Li; Chunhui Wang; Jinlin Yang; Bing Hu; Zhiyin Huang; Rui Ji; Xianbao Zhan; Huizhong Xie; Lei Wang; Mingguang Zhang; Chengwei Tang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pancreas     Volume:  41     ISSN:  1536-4828     ISO Abbreviation:  Pancreas     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8608542     Medline TA:  Pancreas     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1206-12     Citation Subset:  IM    
Affiliation:
From the *Departments of Gastroenterology, West China Hospital, Sichuan University; †Qilu Hospital, Shandong University; ‡Changhai Hospital, The Second Military Medical University; and §The First Hospital Affiliated to Xinjiang Medical University, China.
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