| Prevention of severe acute pancreatitis with octreotide in obese patients: a prospective multi-center randomized controlled trial. | |
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MedLine Citation:
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PMID: 23086244 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVES: To evaluate the efficacy of octreotide in preventing severe acute pancreatitis (SAP) in obese patients. METHODS: A prospective multi-center partly randomized control trial was conducted in patients with mild acute pancreatitis (AP). Nonobese patients received conventional management (nonobese-C, n = 82), whereas obese patients (body mass index ≥25 kg/m) were randomized into 2 groups: obese-C (n = 79), who received conventional management, and obese-C+O (n = 82), who received conventional management plus intravenous infusion of octreotide, 50 μg/h for 72 hours. RESULTS: The risk ratio and relative risk reduction in the development of SAP in the obese-C+O group were 0.27 (95% confidence interval, 0.10-0.69) and 0.73 (95% confidence interval, 0.31-0.90), respectively. The number of cases developing local complications in the obese-C+O group was significantly smaller than that in the obese-C group: 4.9% vs 19%, P = 0.006. The plasma level of somatostatin in the obese-C+O group was significantly higher than that in the obese-C group: 165.5 ± 42.6 vs 112.1 ± 24.86 pg/mL, P < 0.05. Supplement of octreotide also accompanied with reduction in plasma levels of tumor necrosis factor α and IL-6. CONCLUSIONS: Intravenous administration of octreotide (50 μg/h) for 72 hours in the early stage of AP could prevent the development of SAP effectively in obese patients by raising plasma somatostatin to a normal level and reducing circulating cytokines. |
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Authors:
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Fan Yang; Hao Wu; Yanqing Li; Zhaoshen Li; Chunhui Wang; Jinlin Yang; Bing Hu; Zhiyin Huang; Rui Ji; Xianbao Zhan; Huizhong Xie; Lei Wang; Mingguang Zhang; Chengwei Tang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pancreas Volume: 41 ISSN: 1536-4828 ISO Abbreviation: Pancreas Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-10-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8608542 Medline TA: Pancreas Country: United States |
Other Details:
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Languages: eng Pagination: 1206-12 Citation Subset: IM |
Affiliation:
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From the *Departments of Gastroenterology, West China Hospital, Sichuan University; †Qilu Hospital, Shandong University; ‡Changhai Hospital, The Second Military Medical University; and §The First Hospital Affiliated to Xinjiang Medical University, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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