Document Detail

Prevention of scald injury on the peritoneo-serosal surface in advanced gastric cancer patients treated with intraperitoneal hyperthermic perfusion.
MedLine Citation:
PMID:  1919149     Owner:  NLM     Status:  MEDLINE    
In attempts to avoid the side-effects derived from a scald on the peritoneo-serosal surface during intraperitoneal hyperthermic perfusion (IPHP) for advanced gastric cancer, a randomized study using cimetidine, a histamine H2-receptor antagonist, was carried out on 18 patients with advanced gastric cancer. Cimetidine, 50 mg/kg, was administered intravenously and immediately before IPHP. The background characteristics of the patients and the types of surgical treatment used were almost the same between each group of patients, whether or not cimetidine was given. The perfusion time in the cimetidine and control groups was 123 +/- 9 and 117 +/- 9 min, respectively. The inflow and outflow temperatures of the perfusate were 46.3 +/- 0.4 and 44.2 +/- 0.1 degrees C in the cimetidine group, respectively, whereas in the control group the temperatures were 46.0 +/- 0.3 and 44.1 +/- 0.2 degrees C, respectively. In the nine patients who were given cimetidine, the histamine concentrations in the peripheral blood increased significantly, compared to those in the nine controls; this resulted from the release of histamine into the circulating blood. Higher concentrations of protein were observed in the post-hyperthermic intraperitoneal exudate of the control group for 3-24 h after IPHP and, consequently, post-hyperthermic hypoproteinaemia was remarkable in the control group. These data suggest that when pre-IPHP cimetidine was prescribed for patients with gastric cancer treated with IPHP, the peritoneo-serosal surface was protected from scald injury and the side-effects of IPHP were reduced.
S Fujimoto; M Kokubun; R D Shrestha; K Kobayashi; S Kiuchi; C Konno; M Takahashi; K Okui
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group     Volume:  7     ISSN:  0265-6736     ISO Abbreviation:  Int J Hyperthermia     Publication Date:    1991 Jul-Aug
Date Detail:
Created Date:  1991-11-18     Completed Date:  1991-11-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8508395     Medline TA:  Int J Hyperthermia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  543-50     Citation Subset:  IM    
First Department of Surgery, School of Medicine, Chiba University, Japan.
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MeSH Terms
Blood Proteins / metabolism
Burns / blood,  prevention & control*
Cimetidine / administration & dosage,  blood
Histamine / blood
Hyperthermia, Induced / adverse effects*
Middle Aged
Peritoneum / injuries
Stomach Neoplasms / blood,  therapy*
Reg. No./Substance:
0/Blood Proteins; 51-45-6/Histamine; 51481-61-9/Cimetidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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