| Prevention of salt-induced renal injury by activation of NAD(P)H:quinone oxidoreductase 1, associated with NADPH oxidase. | |
| | |
MedLine Citation:
|
PMID: 22227174 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
NADPH oxidase (NOX) is a predominant source of reactive oxygen species (ROS), and the activity of NOX, which uses NADPH as a common rate-limiting substrate, is upregulated by prolonged dietary salt intake. β-Lapachone (βL), a well-known substrate of NAD(P)H:quinone oxidoreductase 1 (NQO1), decreases the cellular NAD(P)H/NAD(P)(+) ratio via activation of NQO1. In this study, we evaluated whether NQO1 activation by βL modulates salt-induced renal injury associated with NOX-derived ROS regulation in an animal model. Dahl salt-sensitive (DS) rats fed a high-salt (HS) diet were used to investigate the renoprotective effect of NQO1 activation. βL treatment significantly lowered the cellular NAD(P)H:NAD(P)(+) ratio and dramatically reduced NOX activity in the kidneys of HS diet-fed DS rats. In accordance with this, total ROS production and expression of oxidative adducts also decreased in the βL-treated group. Furthermore, HS diet-induced proteinuria and glomerular damage were markedly suppressed, and inflammation, fibrosis, and apoptotic cell death were significantly diminished by βL treatment. This study is the first to demonstrate that activation of NQO1 has a renoprotective effect that is mediated by NOX activity via modulation of the cellular NAD(P)H:NAD(P)(+) ratio. These results provide strong evidence that NQO1 might be a new therapeutic target for the prevention of salt-induced renal injury. |
| | |
Authors:
|
Yong-Hoon Kim; Jung Hwan Hwang; Jung-Ran Noh; Gil-Tae Gang; Surendar Tadi; Yong-Hyeon Yim; Nam Ho Jeoung; Tae Hwan Kwak; Sang-Hee Lee; Gi Ryang Kweon; Jin-Man Kim; Minho Shong; In-Kyu Lee; Chul-Ho Lee |
Related Documents
:
|
19666014 - Circulating triglycerides after a high-fat meal: predictor of increased caloric intake,... 9823014 - Effect of enteral nutritional products differing in carbohydrate and fat on indices of ... 11215324 - Hypolipidemic effect of nk-104 and other 3-hydroxy-3-methylglutaryl coenzyme a reductas... 4091004 - Plasma lipoprotein distribution, faecal cholesterol excretion, and activities of lipopr... 1495754 - Effects of switching from a high-fat diet to a low-fat diet on tumor proliferation and ... 20689904 - Nutrient compensatory foraging in a free-living social insect. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-20 |
Journal Detail:
|
Title: Free radical biology & medicine Volume: - ISSN: 1873-4596 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2012-1-9 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8709159 Medline TA: Free Radic Biol Med Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Laboratory Animal Center, Korea Research Institute of Bioscience and Biotechnology, University of Science and Technology, Daejeon 305-806, South Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evaluation of relative importance of ultrasound reactor parameters for the removal of estrogen hormo...
Next Document: Metastatic gastrointestinal stromal tumor to the thoracic and lumbar spine: first reported case and ...