Document Detail

Prevention of recurrent bacterial cystitis by intravesical administration of hyaluronic acid: a pilot study.
MedLine Citation:
PMID:  15180619     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To assess the effect of bladder instillations of hyaluronic acid (HA) on the rate of recurrence of urinary tract infection (UTI). PATIENTS AND METHODS: Forty women (mean age 35 years) with a history of recurrent UTI received intravesical instillations of HA (40 mg in 50 mL phosphate-buffered saline) once weekly for 4 weeks then once monthly for 4 months. The UTI status was assessed over a prospective follow-up of 12.4 months and compared with the rates of UTI before instillation, determined by a retrospective review of patient charts covering 15.8 months. RESULTS: After HA treatment no patients had a UTI during the 5-month treatment phase and 28 (70%) were recurrence-free at the end of the follow-up. The mean (sd) rate of UTI per patient-year was 4.3 (1.55) before treatment and 0.3 (0.55) afterward (P < 0.001). The median time to recurrence after HA treatment was 498 days, compared with 96 days beforehand (P < 0.001). The tolerability was excellent, as side-effects were limited to nine patients who reported mild bladder irritation; no patient interrupted the treatment. CONCLUSIONS: In this preliminary study, bladder instillations of HA had a significant effect on the rate of UTI in women with a history of recurrent UTIs. The bladder instillation of HA is an acceptable and promising therapeutic alternative in patients with recurrent UTI. Expanded placebo controlled clinical trials examining this application of HA are currently underway.
C Constantinides; T Manousakas; P Nikolopoulos; A Stanitsas; K Haritopoulos; A Giannopoulos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  BJU international     Volume:  93     ISSN:  1464-4096     ISO Abbreviation:  BJU Int.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-06-07     Completed Date:  2004-06-29     Revised Date:  2006-07-18    
Medline Journal Info:
Nlm Unique ID:  100886721     Medline TA:  BJU Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  1262-6     Citation Subset:  IM    
1st Department of Urology, University of Athens Medical School, 'Laikon' General Hospital, Athens, Greece.
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MeSH Terms
Adjuvants, Immunologic / administration & dosage*
Administration, Intravesical
Bacterial Infections / prevention & control*
Cystitis / prevention & control*
Cystitis, Interstitial / prevention & control
Follow-Up Studies
Hyaluronic Acid / administration & dosage*
Middle Aged
Pilot Projects
Prospective Studies
Recurrence / prevention & control
Reg. No./Substance:
0/Adjuvants, Immunologic; 9004-61-9/Hyaluronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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