Document Detail

Prevention of preterm delivery: nifedipine or magnesium sulfate.
MedLine Citation:
PMID:  10580682     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: to establish the efficacy and safety of nifedipine and magnesium sulfate in arresting preterm labor. METHOD: seventy-four patients with singleton pregnancies at 23-36 weeks in preterm labor, were selected randomly to receive either oral nifedipine or intravenous magnesium sulfate. RESULTS: both drugs had similar tocolytic efficacy and side effects while nifedipine was faster than magnesium sulfate in arresting uterine contractions (4.8 +/- 4.23 vs. 2.98 +/- 3.03 h) P = 0.04. CONCLUSION: this data suggests that oral nifedipine with the same efficacy, side effects and faster action could be a suitable and more convenient alternative to intravenous magnesium sulfate in arresting preterm labor.
L Haghighi
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics     Volume:  66     ISSN:  0020-7292     ISO Abbreviation:  Int J Gynaecol Obstet     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-12-14     Completed Date:  1999-12-14     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0210174     Medline TA:  Int J Gynaecol Obstet     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  297-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Iran University, Tehran.
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MeSH Terms
Administration, Oral
Injections, Intravenous
Magnesium Sulfate / administration & dosage,  therapeutic use*
Nifedipine / administration & dosage,  therapeutic use*
Obstetric Labor, Premature / prevention & control*
Random Allocation
Tocolytic Agents / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Tocolytic Agents; 21829-25-4/Nifedipine; 7487-88-9/Magnesium Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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