Document Detail


Prevention of preterm birth: early detection and aggressive treatment with terbutaline.
MedLine Citation:
PMID:  8240475     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We evaluated a program for prevention of preterm birth involving early detection and aggressive intervention with subcutaneous terbutaline pump therapy in a high-risk, private patient population. Risk factor screening, frequent cervical examinations, and intensive patient education were used to detect preterm labor before it progressed to an advanced stage. Home terbutaline pump therapy was prescribed for patients with uterine contractions associated with progressive cervical change, after stabilization with IV magnesium sulfate. In this study of 51 patients, home terbutaline pump therapy was successful in 98% of the cases, prolonging pregnancy an average of 6.6 weeks. Mean gestational age at delivery was 37 +/- 1.4 weeks, and infant birth weight averaged 3 kg. Only 22% of infants required admission to the neonatal intensive care unit, with a mean length of stay of 7.25 days. Population factors in this compliant, well-educated patient group may have contributed to the positive outcomes achieved.
Authors:
R T Adkins; J E Van Hooydonk; P L Bressman; J H Growdon; P R Bolen; J C Varin; B R Thompson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  86     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-03-18     Completed Date:  1993-03-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  157-64     Citation Subset:  AIM; IM    
Affiliation:
PharmaThera Inc, Nashville, Tennessee.
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MeSH Terms
Descriptor/Qualifier:
Adult
Birth Weight
Cervix Uteri / pathology
Comorbidity
Drug Therapy, Combination
Female
Follow-Up Studies
Gestational Age
Home Care Services / organization & administration,  standards*
Humans
Infusions, Parenteral
Intensive Care Units, Neonatal / utilization
Length of Stay / statistics & numerical data
Magnesium Sulfate / administration & dosage,  therapeutic use
Male
Mass Screening / standards*
Obstetric Labor, Premature* / diagnosis,  drug therapy,  prevention & control
Patient Compliance
Patient Education as Topic / methods,  standards*
Physical Examination
Pregnancy
Pregnancy Outcome
Program Evaluation
Risk Factors
Self Medication / methods,  standards
Terbutaline / administration & dosage,  adverse effects,  therapeutic use*
Chemical
Reg. No./Substance:
23031-25-6/Terbutaline; 7487-88-9/Magnesium Sulfate
Comments/Corrections
Comment In:
South Med J. 1993 Sep;86(9):1076-7   [PMID:  8367762 ]
South Med J. 1993 Sep;86(9):1076   [PMID:  8240536 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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