Document Detail

Prevention of pregnancy-induced hypertension by calcium supplementation in angiotensin II-sensitive patients.
MedLine Citation:
PMID:  8058229     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the efficacy of oral supplemental calcium in reducing the incidence of pregnancy-induced hypertension (gestational hypertension or preeclampsia) in angiotensin-sensitive nulliparas. METHODS: Sensitivity to intravenously infused angiotensin was determined at 24-28 weeks' gestation in 281 nulliparous women who had positive roll-over tests. Angiotensin-sensitive women were given 2 g/day of oral elemental calcium or placebo in a randomized, double-blind clinical trial. The tablets were dispensed by the hospital pharmacy in serially numbered computerized pill bottles so as to assess compliance. Repeat angiotensin sensitivity test was performed at 34-36 weeks' gestation. RESULTS: Sixty-three of 67 angiotensin-sensitive nulliparas were evaluable; 29 received calcium and 34 received placebo tablets. Four of 29 calcium-treated subjects (13.8%, 95% confidence interval [CI] 4-32%) developed preeclampsia, compared to 15 of 34 (44.1%, 95% CI 27-62%) in the placebo group (relative risk [RR] 0.37, 95% CI 0.15-0.92; P = .01). The incidence of any type of hypertension was nine of 29 (31%, 95% CI 15-51%) with calcium treatment, compared to 22 of 34 (64.7%, 95% CI 46-80%) with placebo (RR 0.46, 95% CI 0.25-0.86; P = .01). CONCLUSION: Calcium supplementation given in pregnancy to high-risk nulliparas reduces the incidence of pregnancy-induced hypertension.
L Sanchez-Ramos; D K Briones; A M Kaunitz; G O Delvalle; F L Gaudier; C D Walker
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  84     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1994-09-09     Completed Date:  1994-09-09     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  349-53     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, University of Florida Health Science Center, Jacksonville.
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MeSH Terms
Angiotensin II / diagnostic use*
Blood Pressure / drug effects
Calcium / administration & dosage,  therapeutic use*
Double-Blind Method
Hypertension / epidemiology,  prevention & control*
Pre-Eclampsia / epidemiology,  prevention & control*
Pregnancy Complications, Cardiovascular / epidemiology,  prevention & control*
Risk Factors
Reg. No./Substance:
11128-99-7/Angiotensin II; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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