Document Detail


Prevention of pregnancy in cats using aglepristone on days 5 and 6 after mating.
MedLine Citation:
PMID:  20451994     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to test for the efficacy of aglepristone treatment for prevention of early pregnancy in the cat. Eleven cats (Gr. 1) were treated with 10 mg/kg aglepristone on days 5 and 6 after mating, 17 cats (Gr. 2) were used as untreated controls. Blood samples for progesterone (P4) determination were collected from 6 cats of Gr. 1 and 9 cats of Gr. 2, respectively. Ultrasound examination on day 25 revealed no pregnancy in any of the treated cats. In both groups, P4 concentrations increased from day 5 (before treatment) to day 20 (P < 0.01). In Gr. 1, the interval between aglepristone treatment and the subsequent estrus ranged from 5-299 d [18.5 (5.2) d]. Mean interestrus interval was 205 +/- 72 d in Gr. 2. Mean duration of subsequent estrus was not different to duration of estrus before treatment in Gr. 1 and in Gr. 2, respectively. Mean time between treatment and next pregnancy was 56.4 (4.7) d, ranging from 5-325 d. Pregnancy rates after the next estrus following treatment were 64 and 82% after the first and second estrus, respectively. No major treatment-related side effects were observed. In conclusion, treatment was found to be highly effective for prevention of early pregnancy.
Authors:
Sandra Goericke-Pesch; Plamen Georgiev; Axel Wehrend
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Publication Detail:
Type:  Journal Article     Date:  2010-05-08
Journal Detail:
Title:  Theriogenology     Volume:  74     ISSN:  1879-3231     ISO Abbreviation:  Theriogenology     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-08     Completed Date:  2010-10-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421510     Medline TA:  Theriogenology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  304-10     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
Clinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Justus-Liebig University, Giessen, Germany. Sandra.Pesch@vetmed.uni-giessen.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Cats*
Contraceptives, Postcoital / adverse effects,  pharmacology*
Copulation
Estrenes / adverse effects,  pharmacology*
Estrus / drug effects,  physiology
Female
Fertility / drug effects
Pregnancy
Pregnancy Rate
Progesterone / blood
Chemical
Reg. No./Substance:
0/Contraceptives, Postcoital; 0/Estrenes; 124478-60-0/aglepristone; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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