Document Detail

Prevention of pre-term labour via the modulation of inflammatory pathways.
MedLine Citation:
PMID:  22348542     Owner:  NLM     Status:  Publisher    
Abstract Pregnancy is characterised by a complex interplay of inflammatory events regulated by both the innate and acquired immune systems. Similarly, parturition can be viewed as the activation of "pro-labour" inflammatory pathways, which drive cervical ripening and myometrial activation. Premature activation of these pathways, for example, by infection, can lead to pre-term labour and birth. Nuclear factor kappa B is a key modulator of these pathways and functions by regulating the expression of prostaglandins, chemokines and pro-inflammatory cytokines involved in both term and pre-term labour. Future design of therapeutics that target key mediators of inflammation and immune activation would therefore be a rational approach for preventing pre-term labour and immune-mediated neonatal brain damage.
David A Macintyre; Lynne Sykes; Tiong Ghee Teoh; Phillip R Bennett
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-21
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Surgery and Cancer, Parturition Research Group, Institute of Reproduction and Developmental Biology, Imperial College London, W120NN, London, UK.
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