Document Detail


Prevention of postischemic spinal cord injury by means of regional infusion of adenosine and L-carnitine dissolved in normothermic saline.
MedLine Citation:
PMID:  15354637     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Spinal cord ischemia still remains an unsolved problem in modern aortic surgery. In this study, we investigated the effectiveness of combined agents such as adenosine and L-carnitine infused to the isolated segment of abdominal aorta in a rabbit model. Twenty-eight rabbits divided into four groups underwent 40 min of isolated infrarenal aortic occlusion. Group I animals received no medication. Group II received an infusion of 100 mg/kg L-carnitine in normothermic saline over the first 10 min of ischemia. Group III received 50 mg adenosine, and group IV received a combination of the two agents in the same fashion. Spinal cord function was evaluated at 24 and 72 hr after operation on the basis of Tarlov scale and similar results were obtained. After a second evaluation, spinal cords were harvested for histological examination. Group I animals were all paraplegics. Spinal cord function was partially intact in two of the group II animals with Tarlov scores of 5 in two and 4 in two whereas one of the rabbits could not hop with a score of 3, and the remaining two could not sit with scores of 1 and 0. The spinal cord function of group III animals was intact with Tarlov scores of 5 in three, 4 in two, and 3 and 1 in remaining ones. In the group IV animals, it was fully intact with Tarlov scores of 5. Histological examination in group I revealed marked enlargement of the vacuoles of glial cells in the white matter of spinal cord. Glial cells were deteriorated in some locations in group II whereas they were mostly protected in the third group. In group IV, histological examination revealed no evidence of spinal cord injury. In conclusion, combined infusion of adenosine and L-carnitine provided better protection against postischemic spinal cord injury than individual infusion of these agents.
Authors:
Osman Tansel Darçin; Lütfü Baktiroğlu; Yaşar Ozkul; Ilyas Ozardali; Mehmet Halit Andaç
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of vascular surgery     Volume:  18     ISSN:  0890-5096     ISO Abbreviation:  Ann Vasc Surg     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-09-09     Completed Date:  2004-11-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8703941     Medline TA:  Ann Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  343-8     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Surgery, Harran University, Faculty of Medicine, Sanliurfa, Turkey. otdarcin@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adenosine / pharmacology*
Animals
Axons / pathology
Blood Pressure / physiology
Carnitine / pharmacology*
Disease Models, Animal
Female
Infusions, Intra-Arterial
Male
Models, Cardiovascular
Neuroglia / pathology
Neuroprotective Agents / pharmacology
Paraplegia / physiopathology,  prevention & control
Rabbits
Reperfusion Injury / complications,  drug therapy,  physiopathology
Sodium Chloride / pharmacology*
Spinal Cord Injuries / etiology*,  physiopathology,  prevention & control*
Spinal Cord Ischemia / complications*,  drug therapy*,  physiopathology
Time Factors
Vasodilator Agents / pharmacology*
Chemical
Reg. No./Substance:
0/Neuroprotective Agents; 0/Vasodilator Agents; 541-15-1/Carnitine; 58-61-7/Adenosine; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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