Document Detail

Prevention of posterior glottic stenosis by mitomycin C.
MedLine Citation:
PMID:  16134354     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Posterior glottic stenosis (PGS) is a disabling disease commonly induced by endolaryngeal injury from intubation or surgery. Few experiments on PGS prevention, however, have been performed. The purpose of this study was to investigate the preventive effect of mitomycin C (MMC) on PGS in a randomized, controlled animal study. METHODS: Twenty-six rabbits underwent laser injury of 6 W, continuous-focus mode on the posterior glottis. There were 6 uninjured controls. Thirteen animals were treated by a single topical use of 0.4 mg/mL MMC solution on the injured posterior glottis for 5 minutes, and 13 were sham-treated controls. The posterior glottis of all groups was blindly evaluated by telescopic examination under direct laryngoscopy 2 months after injury and was harvested for histologic analyses. RESULTS: Scar, granulation tissue, and synechia formation of the posterior glottis were clearly induced by laser injury. Microscopic examination showed increased collagen content and fibroblast proliferation in the region. The use of MMC significantly decreased the incidence of such gross and microscopic changes of the posterior glottis (p < .05). CONCLUSIONS: This study suggests that topical MMC can be helpful in preventing the progression of PGS from mucosal injury of the posterior glottis.
Jong-Lyel Roh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Annals of otology, rhinology, and laryngology     Volume:  114     ISSN:  0003-4894     ISO Abbreviation:  Ann. Otol. Rhinol. Laryngol.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-09-01     Completed Date:  2005-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0407300     Medline TA:  Ann Otol Rhinol Laryngol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  558-62     Citation Subset:  AIM; IM    
Department of Otolaryngology-Head and Neck Surgery, Cancer Research Institute, Chungnam National University College of Medicine, Daejeon, South Korea.
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MeSH Terms
Constriction, Pathologic
Disease Progression
Glottis / pathology*
Granulation Tissue / pathology
Laryngeal Diseases / prevention & control*
Mitomycin / therapeutic use*
Mucous Membrane / pathology
Nucleic Acid Synthesis Inhibitors / therapeutic use*
Reg. No./Substance:
0/Nucleic Acid Synthesis Inhibitors; 50-07-7/Mitomycin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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