Document Detail


Prevention of perinatal HIV transmission: a review of novel strategies.
MedLine Citation:
PMID:  12943497     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Significant progress has been made in preventing transmission of HIV-1 from mother to infant. With combination antiretroviral therapies, transmission rates lower than 2% have been achieved in clinical studies. Abbreviated regimens covering labour and the first few days of neonatal life have shown considerable promise in the developing world. Several questions and challenges remain, however. These include choice of the optimal antiretroviral agent(s) and duration of the regimens, availability of antiretroviral agents in developing countries, long-term safety of antiretrovirals during pregnancy and early neonatal life and the problem of breastfeeding transmission in countries where alternatives to breastfeeding are not available. A wider array of strategies for prevention of mother-to-child transmission of HIV-1 during breastfeeding, including passive and active immunisation, may offer much needed answers to the problem of continued HIV transmission from mother to infant.
Authors:
Athena P Kourtis; Ann Duerr
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert opinion on investigational drugs     Volume:  12     ISSN:  1354-3784     ISO Abbreviation:  Expert Opin Investig Drugs     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-28     Completed Date:  2004-01-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9434197     Medline TA:  Expert Opin Investig Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  1535-44     Citation Subset:  IM    
Affiliation:
Eastern Virginia Medical School, Norfolk, USA. apk3@cdc.gov
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MeSH Terms
Descriptor/Qualifier:
AIDS Vaccines / administration & dosage,  pharmacokinetics
Anti-HIV Agents / therapeutic use*
Breast Feeding / adverse effects
Clinical Trials as Topic
Drug Therapy, Combination
Female
HIV Infections / immunology,  prevention & control*,  transmission*
Humans
Immunization, Passive
Infant
Infant, Newborn
Infectious Disease Transmission, Vertical / prevention & control*
Pregnancy
Vaccination
Chemical
Reg. No./Substance:
0/AIDS Vaccines; 0/Anti-HIV Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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