| Prevention of pain on injection with propofol: a quantitative systematic review. | |
| | |
MedLine Citation:
|
PMID: 10735808 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The best intervention to prevent pain on injection with propofol is unknown. We conducted a systematic literature search (Medline, Embase, Cochrane Library, bibliographies, hand searching, any language, up to September 1999) for full reports of randomized comparisons of analgesic interventions with placebo to prevent that pain. We analyzed data from 6264 patients (mostly adults) of 56 reports. On average, 70% of the patients reported pain on injection. Fifteen drugs, 12 physical measurements, and combinations were tested. With IV lidocaine 40 mg, given with a tourniquet 30 to 120 s before the injection of propofol, the number of patients needed to be treated (NNT) to prevent pain in one who would have had pain had they received placebo was 1.6. The closest to this came meperidine 40 mg with tourniquet (NNT 1.9) and metoclopramide 10 mg with tourniquet (NNT 2.2). With lidocaine mixed with propofol, the best NNT was 2.4; with IV alfentanil or fentanyl, it was 3 to 4. IV lidocaine before the injection of propofol was less analgesic. Temperature had no significant effect. There was a lack of data for all other interventions to allow meaningful conclusions. The diameter of venous catheters and speed of injection had no impact on pain. Implications: IV lidocaine (0.5 mg/kg) should be given with a rubber tourniquet on the forearm, 30 to 120 s before the injection of propofol; lidocaine will prevent pain in approximately 60% of the patients treated in this manner. |
| | |
Authors:
|
P Picard; M R Tramèr |
Related Documents
:
|
17475698 - Pegaptanib and ranibizumab for neovascular age-related macular degeneration: a systemat... 9551418 - Bicarbonate and bicarbonate/lactate peritoneal dialysis solutions for the treatment of ... 8398518 - Dermal anaesthesia: comparison of emla cream with iontophoretic local anaesthesia. 11064608 - Peripheral lidocaine but not ketamine inhibits capsaicin-induced hyperalgesia in humans. 18298508 - Anxiety, depression and pain intensity in patients with low back pain who are admitted ... 10968028 - Anaesthetic management of conjoined twins: experience with six sets of twins. |
Publication Detail:
|
Type: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Anesthesia and analgesia Volume: 90 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 2000 Apr |
Date Detail:
|
Created Date: 2000-04-20 Completed Date: 2000-04-20 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 963-9 Citation Subset: AIM; IM |
Affiliation:
|
Consultation de la douleur, Service de pharmacologie clinique, CHU, Clermont-Ferrand Cedex, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Analgesics, Opioid / therapeutic use Humans Injections / adverse effects* Lidocaine / therapeutic use Pain / prevention & control* Propofol / administration & dosage, adverse effects* Randomized Controlled Trials as Topic Temperature |
| Chemical | |
Reg. No./Substance:
|
0/Analgesics, Opioid; 137-58-6/Lidocaine; 2078-54-8/Propofol |
| Comments/Corrections | |
Comment In:
|
Anesth Analg. 2002 Apr;94(4):1040-1
[PMID:
11916821
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Combitube: a study for proper use.
Next Document: Pentobarbital has curare-like effects on adult-type nicotinic acetylcholine receptor channel current...