Document Detail

Prevention of orofacial clefts: does pregnancy planning have a role?
MedLine Citation:
PMID:  17477752     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the association between pregnancy planning and orofacial clefts in the United Kingdom. DESIGN: Case-control study. SETTING: Scotland and the Manchester and Merseyside regions of England. PARTICIPANTS: One hundred and ninety-one children born with nonsyndromic orofacial cleft, 1997 to 2000, and 247 controls. MAIN OUTCOME MEASURE: Cleft lip with and without cleft palate, and cleft palate. RESULTS: There was an inverse association between planning for pregnancy and orofacial cleft in the offspring (odds ratio [OR] = 0.51, 95% confidence interval [CI] = 0.33-0.79). An unplanned pregnancy together with smoking in the first trimester of pregnancy resulted in almost treble the risk of a child with an orofacial cleft when compared with those who planned their pregnancy and did not smoke (OR = 2.92, CI = 1.50-5.65). CONCLUSIONS: Planned pregnancies were associated with a lower risk of orofacial clefts. Isolation of the elements of pregnancy planning implicated in these results is difficult. Current preconception advice needs to reach a wider audience; however, for maximum impact, efforts are needed to reduce the numbers of unplanned pregnancies.
Peter A Mossey; Janet A Davies; Julian Little
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association     Volume:  44     ISSN:  1055-6656     ISO Abbreviation:  Cleft Palate Craniofac. J.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-04     Completed Date:  2007-06-26     Revised Date:  2007-08-13    
Medline Journal Info:
Nlm Unique ID:  9102566     Medline TA:  Cleft Palate Craniofac J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  244-50     Citation Subset:  D; IM    
University of Dundee, Dental School, Scotland, UK.
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MeSH Terms
Case-Control Studies
Cleft Lip / epidemiology*
Cleft Palate / epidemiology*
England / epidemiology
Family Planning Services
Health Behavior*
Infant, Newborn
Logistic Models
Preconception Care / statistics & numerical data*
Pregnancy Trimester, First
Pregnancy, Unplanned*
Risk Factors
Smoking / epidemiology
Time Factors
Grant Support
04979/Z/96/Z//Wellcome Trust

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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