Document Detail


Prevention of the neoplastic progression of Barrett's oesophagus by endoscopic argon beam plasma ablation.
MedLine Citation:
PMID:  11578292     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Patients with Barrett's oesophagus have a risk of approximately 1 per 100 patient-years for the development of oesophageal adenocarcinoma. Endoscopic ablation of Barrett's oesophagus has been shown to lead to the regrowth of a 'neo' squamous epithelium if gastro-oesophageal reflux is controlled, but the incidence of subsequent tumour formation is unknown. METHODS: The follow-up of 55 patients who underwent endoscopic ablation of Barrett's oesophagus by argon beam plasma coagulation (ABPC) is reported. Of the 55 patients, nine had low-grade dysplasia, nine had high-grade dysplasia and the remainder had non-dysplastic Barrett's metaplasia. Twelve patients had reflux control by antireflux surgery and the remainder received proton pump inhibitor therapy. Barrett's metaplasia was ablated by ABPC to within 2 cm of the gastro-oesophageal junction. RESULTS: To date, one patient has died and one patient was unable to complete treatment. The remaining patients were followed by regular endoscopic surveillance for a mean of 38.5 months to give a total follow-up of 173.5 patient-years. No malignancy has developed in any patient during follow-up. CONCLUSION: The absence of malignant complications in this study of prophylactic ablation of long-segment Barrett's oesophagus strengthens the argument for endoscopic ablation in the prevention of oesophageal adenocarcinoma.
Authors:
C D Morris; J P Byrne; G R Armstrong; S E Attwood
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of surgery     Volume:  88     ISSN:  0007-1323     ISO Abbreviation:  Br J Surg     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-01     Completed Date:  2001-10-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372553     Medline TA:  Br J Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  1357-62     Citation Subset:  AIM; IM    
Affiliation:
Department of Upper Gastrointestinal Surgery, Hope Hospital, Stott Lane, Salford, Manchester M6 8HD, UK.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / prevention & control*
Argon
Barrett Esophagus / prevention & control*
Catheter Ablation / methods*
Disease Progression
Esophageal Neoplasms / prevention & control*
Esophagoscopy / methods*
Follow-Up Studies
Humans
Chemical
Reg. No./Substance:
7440-37-1/Argon
Comments/Corrections
Comment In:
Br J Surg. 2002 May;89(5):626; author reply 626   [PMID:  12019505 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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