| Prevention of nausea and vomiting during termination of pregnancy. | |
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MedLine Citation:
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PMID: 20598689 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Postoperative nausea and vomiting (PONV) is common in women undergoing dilatation and curettage under general anesthesia for pregnancy termination, and many studies suggest treating these women prophylactically for PONV. OBJECTIVES: Reviewing the antiemetics used over the past 20 years for this indication and comparing their efficacy. SEARCH STRATEGY: We performed MEDLINE and EMBASE searches for articles published from January 1980 through June 2009. The search terms were complications, nausea, vomiting, antiemetics, anesthetics, surgery, dilatation, curettage, pregnancy, and women. SELECTION CRITERIA: We selected the studies of the antiemetics droperidol, metoclopramide, hydroxyzine, propofol, dexamethasone, ondansetron, and ramosetron when used for the stated indication. When assessing drug efficacy, we compared the antiemetics used at the time the article was written. DATA COLLECTION AND ANALYSIS: We reviewed the selected studies, presented the reported incidence rates of PONV for each drug, and presented and interpreted the P values reported for the different comparisons. MAIN RESULTS: Although all antiemetics assessed decreased the incidence of PONV, the combination of dexamethasone and droperidol seems to be the most effective in preventing PONV. CONCLUSIONS: All antiemetics used in the last 20 years to prevent PONV are effective (some more than others) in women undergoing dilatation and curettage for pregnancy termination. However, there is a need for benefit and risk analyses of the different treatments. |
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Authors:
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Yoshitaka Fujii |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-07-03 |
Journal Detail:
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Title: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics Volume: 111 ISSN: 1879-3479 ISO Abbreviation: Int J Gynaecol Obstet Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-10 Completed Date: 2010-12-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0210174 Medline TA: Int J Gynaecol Obstet Country: Ireland |
Other Details:
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Languages: eng Pagination: 3-7 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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First Department of Anesthesiology, Toho University School of Medicine, Tokyo, Japan. yfujii@med.toho-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Therapeutic
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adverse effects* Antiemetics / therapeutic use Benzimidazoles / therapeutic use Dexamethasone / therapeutic use Dilatation and Curettage / adverse effects* Droperidol / therapeutic use Drug Therapy, Combination Female Humans Hydroxyzine / therapeutic use Metoclopramide / therapeutic use Ondansetron / therapeutic use Postoperative Nausea and Vomiting / drug therapy, prevention & control* Pregnancy Propofol / therapeutic use Randomized Controlled Trials as Topic |
| Chemical | |
Reg. No./Substance:
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0/Antiemetics; 0/Benzimidazoles; 132907-72-3/ramosetron; 2078-54-8/Propofol; 364-62-5/Metoclopramide; 50-02-2/Dexamethasone; 548-73-2/Droperidol; 68-88-2/Hydroxyzine; 99614-02-5/Ondansetron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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