Document Detail

Prevention of myocardial depression in experimental hemorrhagic shock by pretreatment with hydrocortisone.
MedLine Citation:
PMID:  656016     Owner:  NLM     Status:  MEDLINE    
The left anterior descending or left circumflex coronary artery was cannulated in ten dogs. 4 mg/kg hydrocortisone were slowly infused and the cannula was withdrawn. The dogs were then subjected to hemorrhagic shock for 90 minutes followed by retransfusion. The contractile force (CF) and its first derivative (df/dt) were measured in the pretreated (infused) area and in a control (non-perfused) area of the left ventricle. During the shock period, CF and df/dt in the non-pretreated area showed a 50% reduction in comparison to the pre-shock level, whereas the contractile force in the area that had been pretreated with hydrocortisone did not change when compared to the pre-shock period. This study shows that myocardial depression secondary to hemorrhagic shock can be effectively prevented by pretreatment with hydrocortisone.
G Merin; S Rosenhack; M S Gotsman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Basic research in cardiology     Volume:  73     ISSN:  0300-8428     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:    1978 Jan-Feb
Date Detail:
Created Date:  1978-07-15     Completed Date:  1978-07-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  27-33     Citation Subset:  IM    
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MeSH Terms
Coronary Vessels
Heart Diseases / complications,  prevention & control*
Heart Ventricles
Hydrocortisone / therapeutic use*
Myocardial Contraction
Shock, Hemorrhagic / complications*
Reg. No./Substance:

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